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Publication List

Last updated March 2017


2017

295. Structural insights into the EthR-DNA interaction using native mass spectrometry
DSH Chan, W-G Seetoh, BN McConnell, D Matak-Vinković, SE Thomas, V Mendes, M Claszczyk, AG Coyne, TL Blundell and C Abell
Chem. Commun. (2017)
DOI: 10.1039/C7CC00804J
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294. Surface mediated cooperative interactions of drugs enhance mechanical forces for antibiotic action
JW Ndieyira, J Bailey, SB Patil, M Vögtli, MA Cooper, C Abell, RA McKendry & G Aeppli
Scientific Reports (2017) 7, 41206
DOI: 10.1038/srep41206
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293. A fragment profiling approach to inhibitors of the orphan M. tuberculosis P450 CYP144A1
ME Kavanagh, J Chenge, A Zoufir, KJ McLean, AG Coyne, A Bender, AW Munro, C Abell
Biochemistry (2017)
DOI: 10.1021/acs.biochem.6b00954
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292. Biomimetic supramolecular polymer networks exhibiting both toughness and self-recovery
J Liu, CSY Tan, Z Yu, Y Lan, C Abell, OA Scherman
Adv Mater (2017), 1604951
DOI: 10.1002/adma.201604951
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291. Cucurbit[n]uril-based microcapsules self-assembled within microfluidic droplets: a versatile approach for supramolecular architectures and materials
J Liu, Y Lan, Z Yu, CSY Tan, RM Parker, C Abell, OA Scherman
Acc Chem Res (2017) 50, 208-217
DOI: 10.1039/c6sc04103e
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290. Aqueous interfacial gels assembled from small molecule supramolecular polymers
AS Groombridge, A Palma, RM Parker, C Abell, OA Scherman
Chem. Sci (2017) 8, 1350-1355
DOI: 10.1039/c6sc04103e
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289. Structural characterization and ligand/inhibitor identification provide functional insights into the Mycobacterium tuberculosis cytochrome P450 CYP126A1
JT Chenge, DV Le, S Swami, KJ McLean, ME Kavanagh, AG Coyne, SEJ Rigby, MR Cheesman, HM Girvan, CW Levy, B Rupp, JP von Kries, C Abell, D Leys, AW Munro
J Biol Chem (2017) 292, 1310-1329
DOI: 10.1074/jbc.M116.748822
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2016

288. Fragment-based approaches to TB insight into protein conformation and subcharging by DMSO from native ion mobility mass spectrometry
DSH Chan, D Matak-Vinković, AG Coyne, C Abell
ChemistrySelect (2016) 1, 5686-5690
DOI: 10.1002/slct.201601402
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287. Fragment-based approaches to TB drugs
C Marchetti, DSH Chan, AG Coyne, C Abell
Parasitology (2016), 1-12
DOI: 10.1017/S0031182016001876
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286. Disrupting the constitutive, homodimeric protein-protein interface in CK2β using a biophysical fragment-based approach
W-G Seetoh, C Abell
J Am Chem Soc (2016) 138, 14303-14311
DOI: 10.1021/jacs.6b07440
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285. Label-free analysis and sorting of microalgae and cyanobacteria in microdroplets by intrinsic chlorophyll fluorescence for the identification of fast growing strains
RJ Best, JJ Lyczakowski, S Abalde-Cela, Z Yu, C Abell, AG Smith
Anal Chem (2016) 88, 10445-10451
DOI: 10.1021/acs.analchem.6b02364
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284. Microcapsule buckling triggered by compression-induced interfacial phase change
AR Salmon, RM Parker, AS Groombridge, A Maestro, RJ Coulston, J Hegemann, J Kierfeld, OA Scherman, C Abell
Langmuir (2016) 32, 10987-10994
DOI: 10.1021/acs.langmuir.6b03011
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283. Dual-responsive supramolecular colloidal microcapsules from cucurbit[8]uril molecular recognition in microfluidic droplets
Z Yu, Y Lan, RM Parker, W Zhang, X Deng, OA Scherman, C Abell
Polymer Chemistry (2016) 7, 5996
DOI: 10.1016/j.jmb.2016.10.009
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282. Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51
T Moschetti, T Sharpe, G Fischer, ME Marsh, H Ng, M Morgan, D Scott, TL Blundell, A Venkitaraman, J Skidmore, C Abell, M Hyvönen
J Mol Biol (2016) 428, 4589-4606
DOI: 10.1016/j.jmb.2016.10.009
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281. Hierarchical self-assembly of cellulose nanocrystals in a confined geometry
RM Parker, B Frka-Petesic, G Guidetti, G Kamita, G Consani, C Abell, S Vignolini
ACS Nano (2016) 10, 8443-8449
DOI: 10.1021/acsnano.6b03355
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280. Substrate fragmentation for the design of M. tuberculosis CYP121 inhibitors
ME Kavanagh, JL Gray, SH Gilbert, AG Coyne, KJ McLean, HJ Davis, AW Munro, C Abell
ChemMedChem (2016) 11, 1924-1935
DOI: 10.1002/cmdc.201600248
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279. Inhibition of Ral GTPases using a stapled peptide approach
JC Thomas, JM Cooper, NS Clayton, C Wang, MA White, C Abell, D Owen, HR Mott
J Biol Chem (2016) 291, 18310-18325
DOI: 10.1074/jbc.M116.720243
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278. Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site
M Kasbekar, G Fischer, BT Mott, A Yasgar, M Hyvönen, HI Boshoff, C Abell, CE Barry, CJ Thomas
Proceedings of the National Academy of Sciences of the United States of America (2016) 113, 7503-7508
DOI: 10.1073/pnas.1600630113
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277. Spirooxindoles as novel 3D-fragment scaffolds: synthesis and screening against CYP121 from M. tuberculosis
HJ Davis, ME Kavanagh, T Balan, C Abell, AG Coyne
Bioorg Med Chem Lett (2016) 26, 3735-3740
DOI: 10.1016/j.bmcl.2016.05.073
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276. Small molecules, big targets: drug discovery faces the protein-protein interaction challenge
DE Scott, AR Bayly, C Abell, J Skidmore
Nat Rev Drug Discov (2016)
DOI: 10.1038/nrd.2016.29
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275. Mass spectrometry reveals protein kinase CK2 high-order oligomerization via the circular and linear assembly
WG Seetoh, DS Chan, D Matak-Vinković, C Abell
ACS Chem Biol, (2016) 11, 1151-1517
DOI: 10.1021/acschembio.6b00064
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274. Microfluidic droplet-facilitated hierarchical assembly for dual cargo loading and synergistic delivery
Z Yu, Y Zheng, RM Parker, Y Lan, Y Wu, RJ Coulston, J Zhang, OA Scherman, C Abell
ACS Appl Mater Interfaces, 2016, 8, 8811-8820
DOI: 10.1021/acsami.6b00661
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273. Fragment-based approaches to the development of Mycobacterium tuberculosis CYP121 Inhibitors
ME Kavanagh, AG Coyne, KJ McLean, GG James, CW Levy, LB Marino, LP de Carvalho, DS Chan, SA Hudson, S Surade, D Leys, AW Munro, C Abell
J Med Chem, (2016), 59, 3272-3302
DOI: 10.1021/acs.jmedchem.6b00007
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272. Structure activity relationship of the peptide binding motif mediating the RAD51:BRCA2 protein-protein interaction
DE Scott, M Marsh, TL Blundell, C Abell, M Hyvönen
FEBS letters, 2016, 590, 1094-1102
DOI: 10.1002/1873-3468.12139
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271. Monitoring early-stage nanoparticle assembly in microdroplets by optical spectroscopy and SERS
AR Salmon, R Esteban, RW Taylor, JT Hugall, CA Smith, G Whyte, OA Scherman, J Aizpurua, C Abell, JJ Baumberg
Small, 2016
DOI: 10.1002/smll.201503513
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270. A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters
PO Nikiforov, S Surade, M Blaszczyk, V Delorme, P Brodin, AR Baulard, TL Blundell, C Abell
Org Biomol Chem, 2016, 14, 2318
DOI: 10.1039/C5OB02630J
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269. Structure-based identification of inhibitory fragments targeting the p300/CBP-associated factor bromodomain
A Chaikuad, S Lang, PE Brennan, C Temperini, O Fedorov, J Hollander, R Nachane, C Abell, S Müller, G Siegal, S Knapp
J Med Chem, 2016, 59, 1648
DOI: 10.1021/acs.jmedchem.5b01719
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2015

268. Optimization of inhibitors of Mycobacterium tuberculosis pantothenate synthetase based on group efficiency analysis
A W Hung, H L Silvestre, S Wen, G P George, J Boland, T L Blundell, A Ciulli, C Abell
ChemMedChem, 2016, 11, 38-42
DOI: 10.1002/cmdc.201500414
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267. Supracolloidal architectures self-assembled in microdroplets
X Xu, F Tian, X Liu, R M Parker, Y Wu, Z Yu, O A Sherman, C Abell
Chemistry, 2015, 21, 15516-15519
DOI: 10.1002/chem.201503194
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266. Formation of cucurbit[8]uril-based supramolecular hydrogel beads using droplet-based microfluidics
X Xu, E A Appel, X Liu, R M Parker, O A Scherman, C Abell
Biomacromolecules, 2015, 16, 2743-2749
DOI: 10.1021/acs.biomac.5b01048
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265. The application of ligand-mapping molecular dynamics simulations to the rational design of peptidic modulators of protein-protein interactions
Y S Tan, D R Spring, C Abell, C S Verma
J. Chem. Theory Comput., 2015, 11(7), 3199-3210
DOI: 10.1021/ct5010577
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264. Different flavours of fragments
C Abell, C Dagostin
Fragment-based Drug Discovery, Ch. 1. RSC Drug Discovery Series No. 47, 2015
DOI: 10.1039/9781782620938-00001
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263. Differentially addressable cavities within metal-organic cage-cross-linked polymeric hydrogels
J A Foster, R M Parker, A M Belenguer, N Kishi, S Sutton, C Abell, J R Nitschke
J. Am. Chem. Soc., 2015, 137 (30), 9722-9729
DOI: 10.1021/jacs.5b05507
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262. Supramolecular hydrogel microcapsules via cucurbit[8]uril host-guest interactions with triggered and UV-controlled molecular permeability
Z Yu, J Zhang, R J Coulston, R M Parker, F Biedermann, X Liu, O A Scherman, C Abell
Chem. Sci, 2015, 6 (8): 4929-4933
10.1039/C5SC01440A
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261. High-throughput detection of ethanol-producing cyanobacteria in a microdroplet platform
S Abalde-Cela, A Gould, X Liu, E Kazamia, A G Smith, C Abell
J.R. Soc Interface, 2015, 12, 20150216
DOI: 10.1098/rsif.2015.0216
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260. Surface-immobilised micelles via cucurbit[8]uril-rotaxanes for solvent-induced burst release
C Hu, Y Zheng, Z Yu, C Abell, O A Scherman
Chem. Commun., 2015, 51, 4858
DOI: 10.1039/c5cc00121h
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259. Molecular insights into the binding of coenzyme F420 to the conserved protein Rv1155 from Mycobacterium tuberculosis
E H Mashalidis, A G Gittis, A Tomczak, C Abell, C A Smith, C E Barry, D N Garboczi
Protein Science, 2015, 24, 729-740
DOI: 10.1002/pro.2645
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258. Electrostatically directed self-assembly of ultrathin supramolecular polymer microcapsules
R M Parker, J Zhang, Y Zhang, R J Coulston, C A Smith, A R Salmon, Z Yu, O A Scherman, C Abell
Adv. Funct. Mater, 2015, 25, 4091-4100
DOI: 10.1002/adfm.201501079
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257. Selective targeting of the TPX2 Site of Importin-α using fragment-based ligand design
R S Holvey, E Valkov, D Neal, M Stewart, T L Blundell, C Abell
ChemMedChem, 2015, 10, 1232-1239
DOI: 10.1002/cmdc.201500014
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256. Design and structural analysis of aromatic inhibitors of Type II dehydroquinase from mycobacterium tuberculosis
N I Howard, M V Dias, F Peyrot, L Chen, M F Schmidt, T L Blundell, C Abell
ChemMedChem, 2015, 10 (1), 116-133
DOI: 10.1002/cmdc.201402298
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2014

255. Interfacial assembly of dendritic microcapsules with host-guest chemistry
Y Zheng, Z Yu, R M Parker, Y Wu, C Abell, O A Scherman
Nature Communications, 2014, 5, 5772
DOI: 10.1038/ncomms6772
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254. Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases
D E Scott, A G Coyne, A G Venkitaramen, T L Blundell, C Abell, M Hyvönen
ChemMedChem, 2014, 10 (1), 116-133
DOI: 10.1002/cmdc.201402428
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253. Binding hotspots of BAZ2B bromodomain: Histone interaction revealed by solution NMR driven docking
F M Ferguson, D M Dias, J P Rodrigues, H Wienk, H Boelens, A M Bonvin, C Abell, A Ciulli
Biochemistry,2014, 53 (42), 6706-6716
DOI: 10.1021/bi500909d
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252. Evolution of enzyme catalysts caged in biomimetic gel-shell beads
M Fischlechner, Y Schaerli, M F Mohamed, S Patil, C Abell, F Hollfelder
Nat Chem, 2014, 6 (9), 791-796
DOI: 10.1038/nchem.1996
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251. Regioselective conversion of arenes to N-aryl-1.2.3-triazoles using C-H borylation
R Srinivasen, A G Coyne, C Abell
Chem Eur J, 2014, 20, 11680-11684
DOI: 10.1002/chem.201403021
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250. Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy
S N Mageed, F Cunningham, A W Hung, H L Silvestre, S Wen, T L Blundell, C Abell, G A McConkey
AAC., 2014, 02640-14
DOI: 10.1128/AAC.02640-14
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249. The use of chlorobenzene as a probe molecule in molecular dynamics simulations
Y S Tan, D R Spring, C Abell, C Verma
J. Chem. Inf. Model., 2014
DOI: 10.1021/ci500215x
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248. Supramolecular colloidosomes: fabrication, characterisation and triggered release of cargo
G Stephenson, R M Parker, Y Lan, Z Yu, O A Scherman, C Abell
Chem. Commun., 2014, 50, 7048-7051
DOI: 10.1039/C4CC01479K
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247. Validating fragment-based drug discovery for biological RNAs: lead fragments bind and remodel the TPP riboswitch specifically
K D Warner, P Homan, K M Weeks, A G Smith, C Abell, A R Ferré -D'Amaré
Chem Biol., 2014, 21, 591-595
DOI: 10.1016/j.chembiol.2014.03.007
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246. Threonine 57 is required for the post-translational activation of Escherichia coli aspartate α-decarboxylase
M E Webb, B A Yorke, T Kershaw, S Lovelock, C M Lobley, M L Kilkenny, A G Smith, T L Blundell, A R Pearson, C Abell
Acta Cryst., 2014, D70, 1166-1172
DOI: 10.1107/S1399004713034275
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245. Surface-stress sensors for rapid and ultrasensitive detection of active free drugs in human serum
J W Ndieyira, N Kappeler, S Logan, M A Cooper, C Abell, R A McKendry, G Aeppli
Nat Nanotechnol, 2014, 9, 225-232
DOI: 10.1038/nnano.2014.33
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244. Biofragments: an approach towards predicting protein function using biologically related fragments and its application to mycobacterium tuberculosis CYP126
S A Hudson, E H Mashalidis, A Bender, K J McLean, A W Munro, C Abell
ChemBioChem, 2014, 5, 549-555
DOI: 10.1002/cbic.201300697
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243. Real time dual-channel multiplex SERS ultradetection
S Abalde-Cela, C Abell, R A Alvarez-Puebla, L M Liz-Marzán
J. Phys. Chem. Lett., 2014, 5, 73-79
DOI: 10.1021/jz402419k
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242. Targeting a c-MYC G-quadruplex DNA with a fragment library
H R Nasiri, N M Bell, K I McLuckie, J Husby, C Abell, S Neidle, S Balasubramanian
Chem. Commun., 2014, 50, 1704-1707
DOI: 10.1039/C3CC48390H
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2013

241. Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain
F M Ferguson, O Fedorov, A Chaikuad, M Philpott, J R Muniz, I Felletar, F von Delft, T Heighton, S Knapp, C Abell, A Ciulli
J Med Chem, 2013, 56, 10183-10187
DOI: 10.1021/jm401582c
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240. A three-stage biophysical screening cascade for fragment-based drug discovery
E H Mashalidis, P Śledź, S Lang, C Abell
Nature Protocols, 2013, 8, 2309-2324
DOI: 10.1038/nprot.2013.130
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239. MicroRNA-Specific Argonaute 2 Protein Inhibitors
M F Schmidt, O Korb, C Abell
ACS Chem Biol, 2013, 8, 2122-2126
DOI: 10.1021/cb400246k
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238. Ultrarapid generation of femtoliter microfluidic droplets for single-molecule-counting immunoassays
J U Shim, R T Ranasinghe, C A Smith, S M Ibrahim, F Hollfelder, W T Huck, D Klenerman, C Abell
ACS Nano, 2013, 7, 5955-5964
DOI: 10.1021/nn401661d
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237. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery
H L Silvestre, T L Blundell, C Abell, A Ciulli
Proc. Natl. Acad. Sci. U.S.A, 2013, 110, 12984-9
DOI: 10.1073/pnas.1304045110
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236. Overcoming the limitations of fragment merging: rescuing a strained merged fragment series targeting Mycobacterium tuberculosis CYP121
S A Hudson, S Surade, A G Coyne, K J McLean, D Leys, A W Munro, C Abell
ChemMedChem, 2013, 8, 1451-1456
DOI: 10.1002/cmdc.201300219
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235. Intra-species bacterial quorum sensing studied at single cell level in a double droplet trapping system
Y Bai, S N Patil, S D Bowden, S Poulter, J Pan, G P Salmond, M Welch, W T Huck, C Abell
Int. J. Mol. Sci, 2013, 14, 10570-10581
DOI: 10.3390/ijms140510570
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234. Nanoelectrospray ionization mass spectrometric study of Mycobacterium tuberculosis CYP121-ligand interactions
K M Duffell, S A Hudson, K J McLean, A W Munro, C Abell, D Matak-Vinkovic
Anal Chem, 2013, 85, 5707-5714
DOI: 10.1021/ac400236z
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233. Sensitive, high throughput detection of proteins in individual, surfactant stabilized picoliter droplets using nanoESI mass spectrometry
C Smith, X Li, T H Mize, T D Sharpe, E I Graziani, C Abell, W T S Huck
Anal Chem, 2013, 85, 3812-3816
DOI: 10.1021/ac400453t
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232. Using a fragment-based approach to target protein-protein interactions
D E Scott, M T Ehebauer, T Pukala, M Marsh, T L Blundell, A R Venkitaraman, C Abell, M Hyvönen
ChemBioChem, 14, 332-342
DOI: 10.1002/cbic.201200521
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231. Discovery of Schaeffer's Acid analogues as lead structures of Mycobacterium tuberculosis type II dehydroquinase using a rational drug design approach
M F Schmidt, O Korb, S Lang, N I Howard, M V B Dias, T L Blundell, C Abell
ChemMedChem, 2013, 8, 54-58
DOI: 10.1002/cmdc.201200508
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2012

230. Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of Polo-like kinase 1
Y S Tan, P Śledź, S Lang, C J Stubbs, D R Spring, C Abell, R B Best
Angew. Chem. Int. Ed., 2012, 51, 10078-10081
DOI: 10.1002/anie.201205676
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229. Hierarchical virtual screening for the discovery of new molecular scaffolds in antibacterial hit identification
P J Ballester, M Mangold, N I Howard, R L Robinson, C Abell, J Blumberger, J B Mitchell
J. R. Soc. Interface, 2013, 9, 3196-3207
DOI: 10.1098/rsif. 2012.0569
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228. Application of fragment screening and merging to the discovery of inhibitors of the mycobacterium tuberculosis cytochrome P450 CYP121
S A Hudson, K J McLean, S Surade, Y Q Yang, D Leys, A Ciulli, A W Munro, C Abell
Angew. Chem. Int. Ed. 2012, 51 , 9311-9316
DOI: 10.1002/anie.201202544
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227. High-throughput interrogation of ligand binding mode using a fluorescence-based assay
P Śledź, S Lang, C J Stubbs, C Abell
Angew. Chem. Int. Ed. 2012, 51 , 7680-7683
DOI: 10.1002/anie.201202660
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226. Fragment-based approaches in drug discovery and chemical biology
D Scott, A Coyne, S Hudson, C Abell
Biochemistry 2012, 51, 4990-5003
DOI: 10.1021/bi3005126
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225. Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening
G L Abrahams, A Kumar, S Savvi, A W Hung, S Wen, C Abell, C E Barry III, D R Sherman, H I M Boshoff, V Mizrahi
Chemistry and Biology 2013, 19, 844-54
DOI: 10.1016/j.chembiol.2012.05.020
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224. Mycobacterium tuberculosis cytochrome P450 enzymes: a cohort of novel TB drug targets
S A Hudson, K J McLean, A W Munro, C Abell
Biochem. Soc. Trans. 2012, 40, 573-579
DOI: 10.1042/BST20120062
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223. Ligand-observed NMR in fragment-based approaches
P Śledź, C Abell, A Ciulli
in NMR of biomolecules: towards mechanistic systems biology Edited by I Bertini, K S McGreevy, G Parigi
Wiley-VCH Verlag GmbH & Co. KGaA 2012, 265-280
DOI: 10.1002/9783527644506.ch15
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222. Probing riboswitch-ligand interactions using thiamine pyrophosphate analogues
L Chen, E Cressina, N Dixon, K Erixon, K Agyei-Owusu, J Micklefield, A G Smith, C Abell & F J Leeper
Org. Biomol.Chem 2012, 10, 5924-5931
DOI: 10.1039/C2OB07116A
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221. Structure of Escherichia coli aspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation.
M E Webb, C M C Lobley, F Soliman, M L Kilkenny, A G Smith, T L Blundell & C Abell
Acta Cryst. Section F 2012, F68, 414-417.
DOI: 10.1107/S1744309112009487
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220. Fabrication of microgel particles with complex shape via selective polymerization of aqueous two-phase systems.
S Ma, J Thiele, X Liu, Y Bai, C Abell, W T Huck
Small 2012, 1-5
DOI: 10.1002/smll.201102715
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219. One-step fabrication of supramolecular microcapsules from microfluidic droplets.
J Zhang, R J Coulston, S T Jones, J Geng, O A Scherman & C Abell
Science 2012, 335, 690-694.
DOI: 10.1126/SCIENCE.1215416
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218. Single molecule fluorescence under conditions of fast flow.
M H Horrocks, H Li, J U Shim, R T Ranasinghe, R W Clarke, W T S Huck, C Abell & D Klenerman
Anal. Chem. 2012, 84, 179-185.
DOI: 10.1021/AC202313D
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2011

217. Rv2607 from Mycobacterium tuberculosis is a pyridoxine 5'-phosphate oxidase with unusual substrate specificity.
E H Mashalidis, T Mukherjee, P Śledź, D Matak-Vinković, H Boshoff, C Abell & C E Barry
PLoS One 2011, 6, e27643.
DOI: 10.1371/JOURNAL.PONE.0027643
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216. Quantitative tracking of the growth of individual algal cells in microdroplet compartments.
J Pan, A L Stephenson, E Kazamia, W T S Huck, J S Dennis, A G Smith & C Abell
Integr.Biol. 2011, 3, 1043-1051.
DOI: 10.1039/C1IB00033K
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215. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis.
M V Dias, W C Snee, K M Bromfield, R J Payne, S K Palaninathan, A Ciulli, N I Howard, C Abell, J C Sacchettini & T L Blundell
Biochem 2011, 436, 729-739.
DOI: 10.1042/BJ20110002
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214. Enzyme synthesis and activity assay in microfluidic droplets on a chip.
N Wu, F Courtois, R Surjadi, J Oakeshott, T S Peat, C J Easton, C Abell & Y G Zhu
Eng. Life. Sci. 2011, 11, 157-164.
DOI: 10.1002/elsc.201000043
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213. Identification of novel ligands for thiamine pyrophosphate (TPP) riboswitches.
E Cressina, L Chen, M Moulin, F J Leeper, C Abell & A G Smith
Biochem. Soc. Trans. 2011, 39, 652-657.
DOI: 10.1042/BST0390652
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212. From crystal-packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1.
P Śledź, C J Stubbs, S Lang, Y Yang, G J McKenzie, A R Venkitaraman, M Hyvönen & C Abell
Angew. Chemie Intl. Ed. 2011, 50, 4003-4006.
DOI: 10.1002/anie.201008019
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211. A chelating dendritic ligand capped quantum dot: preparation, surface passivation, bioconjugation and specific DNA detection.
D Zhou, Y Li, E A Hall, C Abell & D Klenerman
Nanoscale 2011, 3, 201-211.
DOI: 10.1039/c0nr00462f
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210. Microdroplet fabrication of silver-agarose nanocomposite beads for SERS optiocal accumulation.
S Abalde-Cela, B Auguié, M Fischlechner, W T S Huck, R A Alvarez-Puebla, L M Liz-Marzán, C Abell
Soft Matter 2011, 7, 1321-1325.
DOI: 10.1039/c0sm00601g
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209. Controlling the contents of microdroplets by exploiting the permeability of PDMS.
J Shim, S N Patil, J T Hodgkinson, S D Bowden, D R Spring, M Welch, W T S Huck, F Hollfelder & C Abell
Lab Chip 2011, 11, 1132-1137.
DOI: 10.1039/c0lc00615g
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208. Monitoring a reaction at sub-millisecond resolution in picoliter volumes.
A Huebner, C Abell, W Huck, C Baroud, F Hollfelder,
Anal. Chem. 2011, 83, 1462-1468.
DOI: 10.1021/ac103234a
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207. Fragment screening against the thiamine pyrophosphate riboswitch thiM.
E Cressina, L H Chen, C Abell, F J Leeper & A G Smith
Chem. Sci 2011, 2, 157-165.
DOI: 10.1039/c0sc00406e
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2010

206. Isothermal DNA amplification using the T4 replisome: circular nicking endonuclease-dependent amplification and primase-based whole-genome amplification.
Y Schaerli, V Stein, M M Spiering, S J Benkovic, C Abell & F Hollfelder
Nucleic Acids Res 2010, 38, e201.
DOI: 10.1093/nar/gkq795
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205. Fluorosurfactants for microdroplets: interfacial tension analysis.
D J Holt, R J Payne, W Y Chow & C Abell
J. Colloid Interface Sci 2010, 350, 205-211.
DOI: 10.1016/j.jcis.2010.06.036
PDF
204. Hydrophilic PDMS microchannels for high-throughput formation of oil-in-water microdroplets and water-in-oil-in-water double emulsions.
W-A C Bauer, M Fischlechner, C Abell & W T S Huck
Lab Chip 2010, 10, 1814-1819.
DOI: 10.1039/c004046k
PDF
203. Management of the diffusion of 4-methylumbelliferone across phases in microdroplet-based systems for in vitro protein evolution.
N Wu, F Courtois, Y G Zhu, J Oakeshott, C Easton & C Abell
Electrophoresis 2010, 31, 3121-3128.
DOI: 10.1002/elps.201000140
PDF
202. Inhibition of chorismate-utilising enzymes by 2-amino-4-carboxypyridine and 4-carboxypyridone and 5-carboxypyridone analogues.
R J Payne, E M Bulloch, O Kerbarh & C Abell
Org. Biomol. Chem 2010, 8, 3534-3542.
DOI: 10.1039/c004062b
PDF
201. Optimisation of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase.
P Sledź, H L Silvestre, A W Hung, A Ciulli, T L Blundell & C Abell
J. Am. Chem. Soc. 2010, 132, 4544-4545.
DOI: 10.1021/ja100595u
PDF
200. A fragment-based approach to identifying ligands for riboswitches.
L Chen, E Cressina, F J Leeper, A G Smith & C Abell
A.C.S. Chem. Biol. 2010, 5, 355-358.
DOI: 10.1021/cb9003139
PDF
199. Drugging challenging targets using fragment-based approaches.
A G Coyne, D E Scott, & C Abell
Curr. Opin. Chem. Biol. 2010, 14, 299-307.
DOI: 10.1016/j.cbpa.2010.02.010
PDF
198. Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology.
A B Theberge, F Courtois, Y Schaerli, M Fischlechner, C Abell, F Hollfelder & W T S Huck
Angew. Chemie Int. Ed. 2010, 49, 5846-5868.
DOI: 10.1002/anie.200906653
PDF
197. A double droplet trap system for studying mass transport across a droplet-droplet interface.
Y Bai, X He, D Liu, S N Patil, D Bratton, A Huebner, F Hollfelder, C Abell & W T S Huck
Lab Chip 2010, 10, 1281-1285.
DOI: 10.1039/b925133b
PDF
196. Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activities of chorismate-utilizing enzymes.
S Sridharan, N Howard, O Kerbarh, M Blaszczyk, C Abell & T L Blundell
J. Mol. Biol. 2010, 397, 290-300.
DOI: 10.1016/j.jmb.2010.01.019
PDF
195. Tri-partite complex for axonal transport drug delivery achieves pharmacological effect.
A G Filler, G T Whiteside, M Bacon, M Frederickson, F A Howe, M D Rabinowitz, A J Sokoloff, T W Deacon, C Abell, R Munglani, J R Griffiths, B A Bell & A M L Lever
B.M.C. Neuroscience 2010, 11, 8.
DOI: 10.1186/1471-2202-11-8
PDF
194. Synthesis of novel fluorous surfactants for microdroplet stabilisation in fluorous oil streams.
D J Holt, R J Payne & C Abell
J. Fluorine Chemistry 2010, 131, 398-407.
DOI: 10.1016/j.jfluchem.2009.12.010
PDF
193. Vancomycin dimer formation between analogues of bacterial peptidoglycan surfaces probed by force spectroscopy.
M Batchelor, D Zhou, M A Cooper, C Abell & T Rayment
Org. Biomol. Chem. 2010, 8, 1142-1148.
DOI: 10.1039/b919347b
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2009

192. Simultaneous determination of gene expression and enzymatic activity in individual bacterial cells in microdroplet compartments.
J-U Shim, L F Olguin, G Whyte, D Scott, A Babtie, C Abell, W T S Huck & F Hollfelder
J. Am. Chem. Soc. 2009, 131, 15251-15256
DOI: 10.1021/ja904823z
PDF
191. Bio-functionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platforms.
J Gautrot, J Trmcic-Cvitas, E Hasan, M Ramstedt, X Li, M Cooper, C Abell & W Huck
Biomacromolecules 2009, 10, 2885-2894.
DOI: 10.1021/bm900706r
PDF
190. A fragment-based approach to probing adenosine recognition sites using dynamic combinatorial chemistry.
D E Scott, G J Dawes, C Abell & A Ciulli
ChemBioChem 2009 10, 17, 2772 - 2779
DOI:10.1002/cbic.200900537
PDF
189. Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase.
A W Hung, H L Silvestre, S Wen, A Ciulli, T L Blundell & C Abell
Angew. Chemie Intl. Ed. 2009, 48, 8452-8456.
DOI:10.1002/anie.200903821
PDF
188. Fragment-based drug discovery in academia: experiences from a tuberculosis programme.
T J Heikkila, S Surade, H L Silvestre, M V B Dias, A Ciulli, K M Bromfield, D E Scott, N I Howard, S Wen, A H Wei, D M Osborne, C Abell & T L Blundell
In Proceedings of the NATO International School of Crystallography, 40th Course 'From Molecules to Medicine: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism'. J. L. Sussman and P. Spadon, Ed., Springer, 2009, 21-36.
ISBN: 978-90-481-2337-7
187. Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays.
F Courtois, L F Olguin, G Whyte, A Theberge, W T S Huck, F Hollfelder & C Abell
Anal. Chem. 2009, 81, 3008-3016.
DOI:10.1021/ac802658n
PDF
186. Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of chorismate utilising enzymes.
R J Payne, E M M Bulloch, M M Toscano, O Kerbarh & C Abell
Org. Biomol. Chem. 2009, 7, 2421-2429.
DOI:10.1039/b901694e
PDF
185. An integrated cell culture lab on a chip: modular microdevices for cultivation of mammalian cells and delivery into microfluidic microdroplets.
H Hufnagel , A Huebner, C Gülch, K Güse, C Abell & F Hollfelder
Lab Chip 2009, 9, 1576-1582.
DOI:10.1039/b821695a
PDF
184. Simultaneous measurement of reactions in microdroplets filled by concentration gradients.
N Damean, L F Olguin, F Hollfelder, C Abell & W T S Huck
Lab Chip 2009, 9, 1707-1713.
DOI:10.1039/b821021g
PDF
183. Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets on line.
L M Fidalgo, G Whyte, B T Ruotolo, J L P Benesch, F Stengel, C Abell, C V Robinson & W T S Huck
Angew. Chimie Intl. Ed. 2009, 48, 3665-3668.
DOI:10.1002/anie.200806103
PDF
182. Continuous-flow polymerase chain reaction of single-copy DNA in microfluidic microdroplets.
Y Schaerli, R C Wootton, T Robinson, V Stein, C Dunsby, M A A Neil, P M W French, A J deMello, C Abell & F Hollfelder
Anal. Chem. 2009, 81, 302-306.
DOI:10.1021/ac802038c
PDF
181. Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays.
A Huebner, D Bratton, G Whyte, M Yang, A J deMello, C Abell & F Hollfelder
Lab Chip 2009, 9, 692-698.
DOI:10.1039/b813709a
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2008

180. Towards engineering increased pantothenate (Vitamin B5) levels in plants.
E Chakauya, K M Coxon, M Wei, M V MacDonald, T Barsby, C Abell & A G Smith.
Plant Mol. Biol. 2008, 68, 1-46.
DOI:10.1007/s11103-008-9386-5
PDF
179. Nanomechanical detection of antibiotic–mucopeptide binding in a model for superbug drug resistance.
J W Ndieyira, M Watari, A D Barrera, M Batchelor, D Zhou, M A Cooper, T Strunz, B Dueck, C Abell, M A Horton, T Rayment, G Aeppli & R A McKendry
Nature Nanotechnology 2008, 3, 691-696
DOI:10.1038/nnano.2008.275
PDF
178. Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate.
A Ciulli, D E Scott, M Ando, F Reyes, S A Saldanha, K L Tuck, D Y Chirgadze, T L Blundell & C Abell
ChemBioChem 2008, 9, 2606-2611.
DOI:10.1002/cbic.200800437
PDF
177. Development of quantitative cell-based enzyme assays in microdroplets.
A Huebner, L F Olguin, D Bratton, G Whyte, W T S Huck, A J de Mello, J B Edel, C Abell & F Hollfelder
Anal. Chem. 2008, 80, 3890-3896.
DOI:10.1021/ac800338z
PDF
176. From microdroplets to microfluidics: selective emulsion separation in microfluidic devices.
L M Fidalgo, G Whyte, D Bratton, C Abell & W T S Huck
Angew. Chimie Intl. Ed. 2008, 47, 2042-2045.
DOI:10.1002/anie.200704903
PDF
175. A compact functional quantum dot-DNA conjugate: preparation, hybridization and specific label-free DNA detection.
D Zhou, L Ying, X Hong, E A Hall, C Abell & D Klenerman
Langmuir 2008, 24, 1659-1664.
DOI:10.1021/la703583u
PDF
174. An integrated device for monitoring time-dependent in vitro expression from single genes in picolitre droplets.
F Courtois, L F Olguin, G Whyte, D Bratton, W T S Huck, C Abell & F Hollfelder
ChemBioChem 2008, 9, 439-446.
DOI:10.1002/cbic.200700536
PDF
173. Discovery and extrapolation of fragment structures towards drug design.
A Ciulli, T L Blundell, & C Abell
In 'Computational and structural approaches to drug discovery" Ed R M Stroud, J Finer-Moore, 2008, Royal Society of Chemistry, pp 293-318.
ISBN:978-0-85404-365-1
172. Single step biocompatible coating for sulfhydryl coupling of receptors using 2-(pyridinyldithio)ethyl-carbamoyl dextran.
X Li, C Abell & M A Cooper
Colloids and Surfaces B: Biointerfaces 2008, 61, 113-117.
DOI:10.1016/j.colsurfb.2007.06.026
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2007

171. Fragment-based approaches to enzyme inhibition.
A Ciulli & C Abell
Curr. Op. Biotech. 2007, 18, 489-496.
DOI:10.1016/j.copbio.2007.09.003
PDF
170. Investigating specific interactions between carbonic anhydrase and a sulfonamide inhibitor by single molecule force spectroscopy.
S G Kamper, L Porter-Peden, R Blankespoor, K Sinniah, D Zhou, C Abell & T Rayment
Langmuir 2007 23, 12561-12565.
DOI:10.1021/la702148v
PDF
169. Coenzyme biosynthesis: enzyme mechanism, structure and inhibition.
D E Scott, A Ciulli & C Abell
Nat. Prod. Reports 2007, 24, 1009-1026.
DOI:10.1039/b703108b
PDF
168. Surface-induced droplet fusion in microfluidic devices.
L M Fidalgo, C Abell & W T S Huck
Lab Chip 2007, 7, 984-986.
DOI:10.1039/b708091c
PDF
167. Design, synthesis and structural studies on potent biaryl inhibitors of type II dehydroquinases
R J Payne, A Riboldi-Tunnicliffe, O Kerbarh, A D Abell, A J Lapthorn & C Abell
ChemMedChem 2007, 2, 1010-1013.
DOI:10.1002/cmdc.200700062
PDF
166. Rational design, synthesis and evaluation of nanomolar type II dehydroquinase inhibitors.
R J Payne, F Peyrot, O Kerbarh, A D Abell, & C Abell
ChemMedChem 2007, 2, 1015-1029.
DOI:10.1002/cmdc.200700032
PDF
165. Nucleophile selectivity of chorismate-utilizing enzymes.
O Kerbarh, A Ciulli, D Y Chirgadze, T L Blundell & C Abell
ChemBioChem 2007, 8, 622-624.
DOI:10.1002/cbic.200700019
PDF
164. Quantitative detection of protein expression in single cells using droplet microfluidics.
A Huebner, M Srisa-Art, D Holt, C Abell, F Hollfelder, A J deMello & J B Edel
Chem. Commun. 2007, 1218-1220.
DOI:10.1039/b618570c
PDF
163. Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change and cooperativity.
A Ciulli, D Y Chirgadze, A G Smith, T L Blundell & C Abell
J. Biol. Chem. 2007, 282, 8487-8497.
DOI:10.1074/jbc.M611171200
PDF
162. Nanomolar inhibition of type II dehydroquinase based on the enolate reaction mechanism.
M D Toscano, R J Payne, A Chiba, O Kerbarh & C Abell
ChemMedChem 2007, 2, 101-112.
DOI:10.1002/cmdc.200600194
PDF
161. pH tuneable binding of 2'-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study.
A Ciulli, C M C Lobley, K L Tuck, A G Smith, T L Blundell & C Abell
Acta Cryst. 2007, D63, 171-178.
DOI:10.1107/S0907444906044465
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2006

160. The design and synthesis of inhibitors of pantothenate synthetase.
K L Tuck, S A Saldanha, L M Birch, A G Smith & C Abell
Org. Biomol. Chem. 2006, 4, 3598-3610.
DOI:10.1039/b609482a
PDF
159. Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods.
A Ciulli, G Williams, A G Smith, T L Blundell & C Abell
J. Med. Chem. 2006, 49, 4992-5000.
DOI:10.1021/jm060490r
PDF
158. Building three-dimensional nanostructures with active enzymes by surface templated layer-by-layer assembly.
S Rauf, D Zhou, C Abell, D Klenerman & D-J Kang
Chem. Commun. 2006, 1721-1723.
DOI:10.1039/b517557g
PDF
157. Macroscopic, 2D networks self-assembled from nanometre-sized protein/DNA complexes.
M Manzanera, D J Frankel, H Li, D Zhou, A Bruckbauer, P Kreutzmann, J M Blackburn, C Abell, T Rayment, D Klenerman & P D Barker
Nano Lett. 2006, 6, 365-370.
DOI:10.1021/nl051599+
PDF
156. Pantothenate biosynthesis in higher plants: advances and challenges.
E Chakauya, K M Coxon, H M Whitney, J L Ashurst, C Abell & A G Smith
Physiologia Plantarum 2006, 126, 319-329.
DOI:10.1111/j.1399-3054.2006.00683.x
PDF
155. Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors.
N Howard, C Abell, W Blakemore, R Carr, G Chessari, M Congreve, S Howard, H Jhoti, C W Murray, L C A Seavers & R L M van Montfort
J. Med. Chem. 2006, 49, 1346-1355.
DOI:10.1021/jm050850v
PDF
154. A reversible pH-Driven DNA nanoswitch array.
D Liu, A Bruckbauer, C Abell, S Balasubramanian, D-J Kang, D Klenerman & D Zhou
J. Am. Chem. Soc. 2006, 128, 2067-2071.
DOI:10.1021/ja0568300
PDF
153. Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate.
O Kerbarh, D Y Chirgadze, T L Blundell & C Abell
J. Mol. Biol. 2006, 357, 524-534.
DOI:10.1016/j.jmb.2005.12.078
PDF
152. Electrostatic orientation of enzymes on surfaces for ligand screening probed by force spectroscopy.
X Wang, D Zhou, K Sinniah, C Clarke, L Birch, H Li, T Rayment & C Abell
Langmuir 2006, 22, 887-892.
DOI:10.1021/la0525731
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2005

151. Design and synthesis of aromatic inhibitors of anthranilate synthase - part II.
R J Payne, E M M Bulloch, A D Abell & C Abell
Org. Biomol. Chem. 2005, 3, 3629-3635.
DOI:10.1039/b510633h
PDF
150. Rational design of new bifunctional inhibitors of type II dehydroquinase.
M D Toscano, K A Stewart, J R Coggins, A J Lapthorn & C Abell
Org. Biomol. Chem. 2005, 3, 3102-3104.
DOI:10.1039/b507156a
PDF
149. Fluorescence resonance energy transfer between a quantum dot donor and a dye acceptor attached to DNA.
D J Zhou, J D Piper, C Abell, D Klenerman, D J Kang & L M Ying
Chem. Commun. 2005, 4807-4809.
DOI:10.1039/b508911e
PDF
148. Biophysical tools to monitor enzyme-ligand interactions of enzymes involved in vitamin biosynthesis.
A Ciulli & C Abell
Biochem. Soc. Trans. 2005, 33, 767-771.
PDF
147. Mechanistic and inhibition studies of chorismate-utilizing enzymes.
O Kerbarh, E M M Bulloch, R J Payne, T Sahr, F Rabeille & C Abell
Biochem. Soc. Trans. 2005, 33, 763-766.
PDF
146. Pantothenate biosynthesis in higher plants.
K M Coxon, E Chauauya, H H Ottenhof, H M Whitney, T L Blundell, C Abell & A G Smith
Biochem. Soc. Trans. 2005, 33, 743-746.
PDF
145. Salicylate biosynthesis: over-expression, purification and characterization of Irp9, a bifunctional salicylate synthase from Yersinia enterocolitica.
O Kerbarh A Ciulli, N Howard & C Abell
J. Bact. 2005, 187, 5061-5066.
DOI:10.1128/JB.187.15.5061-5066.2005
PDF
144. The crystal structure of Escherichia coli ketopantoate reductase in complex with NADP+ bound.
C M C Lobley, A Ciulli, H Whitney, G Williams, A G Smith, C Abell & T L Blundell
Biochemistry 2005, 44, 8930-8939.
DOI:10.1021/bi0502036
PDF
143. Design and synthesis of aromatic inhibitors of anthranilate synthase.
R J Payne, M Toscano, E M Bulloch, A D Abell & C Abell
Org. Biomol. Chem. 2005, 3, 2271-2281.
DOI:10.1039/b503802b
PDF
142. Inhibition studies on salicylate synthase.
R J Payne, O Kerbarh, R N Miguel, A D Abell & C Abell
Org. Biomol. Chem. 2005, 3, 1825-1827.
DOI:10.1039/b503800f
PDF
141. Fabrication of 3D surface structures with highly fluorescent quantum dots by surface-templated layer-by-layer assembly.
D Zhou, A Bruckbauer, C Abell, D Klenerman & D-J Kang
Advanced Materials 2005, 17, 1243-1248.
DOI:10.1002/adma.200401520
PDF
140. Detection of covalent intermediates formed in the reaction of 4 amino 4 deoxychorismate synthase.
E M M Bulloch & C Abell
ChemBioChem 2005, 6, 832-834.
DOI:10.1002/cbic.200400385
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2004

139. Biosynthesis of pantothenate.
M E Webb, A G Smith & C Abell
Nat. Prod. Rep. 2004, 21, 695-721.
DOI:10.1039/b316419p
PDF
138. A simple voltage controlled enzymatic nanoreactor produced in the tip of a nanopipet.
A Bruckbauer, D Zhou, L Ying, C Abell & D Klenerman
Nano. Lett. 2004, 4, 1859-1862.
DOI:10.1021/nl049029h
PDF
137. Influence of the foundation layer on the layer-by-layer assembly of poly-L-lysine and poly(styrenesulfonate) and its usage in the fabrication of 3D microscale features.
D Zhou, A Bruckbauer, M Batchelor, D-J Kang, C Abell & D Klenerman
Langmuir 2004, 20, 9089-9094.
DOI:10.1021/la048619s
PDF
136. Identification of 4-amino-4-deoxychorismate synthase as the molecular target for the antimicrobial action of (6S)-6-fluoroshikimate.
E M M Bulloch, M A Jones, E J Parker, A P Osborne, E Stimson, G M Davies, J R Coggins & C Abell
J. Am. Chem. Soc. 2004, 126, 9912-9913.
DOI:10.1021/ja048312f
PDF
135. (1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalysed by type II dehydroquinases.
M Frederickson, A W Roszak, J R Coggins, A J Lapthorn & C Abell
Org. Biomol. Chem. 2004, 2, 1592-1596.
DOI:10.1039/b404535a
PDF
134. An addressable antibody nanoarray produced on a nanostructured surface.
A Bruckbauer, D Zhou, D-J Kang, Y E Korchev, C Abell & D Klenerman
J. Am. Chem. Soc. 2004, 126, 6508-6509.
DOI:10.1021/ja0317426
PDF
133. A novel phase-switching protecting group for multi-step parallel solution phase synthesis.
X Li, C Abell, M S Congreve, B Warrington & M Ladlow
Org. Biomol. Chem. 2004, 2, 989-998.
DOI:10.1039/b400110a
PDF
132. Method to determine the spring constant of atomic force microscope cantilevers.
C T Gibson, D J Johnson, C Anderson, C Abell & T Rayment
Rev. Sci. Instrum. 2004, 75, 565-567.
DOI:10.1063/1.1642750
PDF
131. Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants.
H H Ottenhof, J L Ashurst, H M Whitney, S A Saldanha, F Schmitzberger, H S Gweon, T L Blundell, C Abell & A G Smith
Plant J. 2004, 37, 61-72.
DOI:10.1046/j.1365-313X.2003.01940.x
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2003

130. Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia).
X Li, C Abell, B Warrington & M Ladlow
Org. Biomol. Chem. 2003, 1, 4392-4395.
DOI:10.1039/b307549d
PDF
129. Structural constraints on protein self-processing in L-aspartate-α-decarboxylase.
F Schmitzberger, M L Kilkenny, C M C Lobley, M E Webb, M Vinkovic, D Matak-Vinkovic, M Witty, D Y Chirgadze, A G Smith, C Abell & T L Blundell
EMBO J. 2003, 22, 6193-6204.
DOI:10.1093/emboj/cdg575
PDF
128. AFM study on protein immobilization on charged surfaces at the nanoscale: towards the fabrication of three-dimensional protein nanostructures.
D Zhou, X Wang, L Birch, T Rayment & C Abell
Langmuir 2003, 19, 10557-10562.
DOI:10.1021/la035491q
PDF
127. Parallel solid-phase synthesis and evaluation of inhibitors of Streptomyces coelicolor type II dehydroquinase.
C González-Bello, E Lence, M D Toscano, L Castedo, J R Coggins & C Abell
J. Med. Chem. 2003, 46, 5735-5744.
DOI:10.1021/jm030987q
PDF
126. Building three-dimensional surface biological assemblies on the nanometer scale.
D Zhou, A Bruckbauer, L Ying, C Abell & D Klenerman
Nano. Lett. 2003, 3, 1517-1520.
DOI:10.1021/nl0345926
PDF
125. Enzymic synthesis of 3-[3-13C]dehydroquinic acid.
M Frederickson, E J Parker, J R Coggins & C Abell
Org. Biomol. Chem. 2003, 1, 3271-3273.
DOI:10.1039/b309666a
PDF
124. Novel selenium containing non-detergent sulphobetaines.
M Frederickson, L Vuillard & C Abell
Tetrahedron Lett. 2003, 44, 7925-7928.
DOI:10.1016/j.tetlet.2003.09.004
PDF
123. Rapid screening by MALDI-TOF mass spectrometry to probe binding specificity at enzyme active sites.
M E Webb, E Stephens, A G Smith & C Abell
Chem. Commun. 2003, 2416-2417.
DOI:10.1039/b308182f
PDF
122. Label-free detection of DNA hybridisation at the nanoscale: a highly sensitive and selective approach using atomic-force microscopy.
D Zhou, K Sinniah, C Abell & T Rayment
Angewandte Chemie 2003, 42, 4934-4937.
DOI:10.1002/anie.200352178
PDF
121. Multicomponent submicron features of biomolecules created by voltage controlled deposition from a nanopipet.
A Bruckbauer, D Zhou, L Ying, Y E Korchev, C Abell & D Klenerman
J. Am. Chem. Soc. 2003, 125, 9834-9839.
DOI:10.1021/ja035755v
PDF
120. Design, synthesis and evaluation of bifunctional inhibitors of type II dehydroquinase.
M D Toscano, M Frederickson, D P Evans, J R Coggins, C Abell & C González-Bello
Org. Biol. Chem. 2003, 1, 2075-2083.
DOI:10.1039/b301731a
PDF
119. Comparative analysis of the Escherichia coli ketopantoate hydroxymethyltransferase crystal structure confirms it as a member of the (βα)8 phosphoenolpyruvate/pyruvate superfamily.
F Schmitzberger, A G Smith, C Abell & T L Blundell
J. Bacteriol. 2003, 185, 4163-4171.
DOI:10.1128/JB.185.14.4163-4171.2003
PDF
118. Structural insights into the evolution of the pantothenate-biosynthesis pathway.
C M C Lobley, F Schmitzberger, M L Kilkenny, H Whitney, H H Ottenhof, E Chakauya, M E Webb, L M Birch, K L Tuck, C Abell, A G Smith & T L Blundell
Biochem. Soc. Trans. 2003, 31, 563-571.
PDF
117. Experiences with the shikimate-pathway enzymes as targets for rational drug design.
J R Coggins, C Abell, L B Evans, M Frederickson, D A Robinson, A W Roszak & A J Lapthorn
Biochem. Soc. Trans. 2003, 31, 548-552.
PDF
116. Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites.
F von Delft, T Inoue, S A Saldanha, H H Ottenhof, F Schmitzberger, L M Birch, V Dhanaraj, M Witty, A G Smith, T L Blundell & C Abell
Structure 2003, 11, 985-996.
DOI:10.1016/S0969-2126(03)00158-8
PDF
115. A novel anthracenyl tagged protecting group for "phase-switching" applications in parallel synthesis.
X Li, C Abell & M Ladlow
J. Org. Chem. 2003, 68, 4189-4194.
DOI:10.1021/jo034219i
PDF
114. A convenient method for the synthesis of dehydroquinic acid.
C Le Sann, C Abell & A D Abell
Synth. Comm. 2003, 33, 527-533.
DOI:10.1081/SCC-120015805
PDF
113. Chiral discrimination of basic and hydrophobic molecules by chemical force microscopy.
M Mahapatro, C Gibson, C Abell & T Rayment
Ultramicroscopy 2003, 97, 297-301.
DOI:10.1016/S0304-3991(03)00055-X
PDF
112. Calibration of AFM cantilever spring constants.
C T Gibson, B L Weeks, C Abell, T Rayment & S Myhra
Ultramicroscopy 2003, 97, 113-118.
DOI:10.1016/S0304-3991(03)00035-4
PDF
111. Systematic manipulation of surface chemical reaction on the nanoscale: a novel approach for constructing three-dimensional nanostructures.
X Wang, D Zhou, T Rayment & C Abell
Chem. Commun. 2003, 474-476.
DOI:10.1039/b211906d
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2002

110. A sensitive and economical method to directly detect particles.
M A Cooper, V P Ostanin, D Klenerman, A Slepstov, R Karamanska, F N Dultsev, K Stirrups, S Kelling, T Minson & C Abell
Proceedings of IEEE Sensors 2002, 1,1042-1045.
109. High-throughput x-ray crystallography for drug discovery.
T L Blundell, C Abell, A Cleasby, M J Hartshorn, I J Tickle, E Parasini & H Jhoti
In "Drug design, cutting edge approaches" Ed. D Flower
Royal Soc. Chem. 2002, 53-59.
ISBN: 0-85404-816-2
108. The use of FTICR-MS to detect chemical tags from a combinatorial library.
M H Todd & C Abell
Analyst 2002, 127, 1399-1406.
DOI:10.1039/b203957p
PDF
107. The use of atomic force microscopy for making addresses in DNA coatings.
D Zhou, K Sinniah, C Abell & T Rayment
Langmuir 2002, 18, 8278-8281.
DOI:10.1021/la0258547
PDF
106. A simple method for the preparation of 3-hydroxyiminodehydroquinate, a potent inhibitor of type II dehydroquinase.
C Le Sann, C Abell & A D Abell
Perkin Trans I 2002, 2065-2068.
DOI:10.1039/b206066c
PDF
105. Vinyl fluoride as an isoelectronic replacement for an enolate anion: inhibition of type II dehdyroquinases.
M Frederickson, J R Coggins & C Abell
Chem. Commun. 2002, 1886-1887.
DOI:10.1039/b205105m
PDF
104. Writing with DNA and protein using a nanopipet for controlled delivery.
A Bruckbauer, L Ying, A M Rothery, D Zhou, A I Shevchuk, C Abell, Y E Korchev & D Klenerman
J. Am. Chem. Soc. 2002, 124, 8810-8811.
DOI:10.1021/ja026816c
PDF
103. Creating nanoscale patterns of dendrimers on silicon surfaces with dip-pen nanolithography.
R McKendry, W T S Huck, B Weeks, M Fiorini, C Abell & T Rayment
Nano Letts. 2002, 2, 713-716.
DOI:10.1021/nl020247p
PDF
102. The structure and mechanism of type II dehydroquinase from Streptomyces coelicolor.
A W Roszak, D A Robinson, T Krell, I S Hunter, M Frederickson, C Abell, J R Coggins & A J Lapthorn
Structure 2002, 10, 493-503.
DOI:10.1016/S0969-2126(02)00747-5
PDF
101. High throughput crystallography for lead discovery in drug design.
T L Blundell, H Jhoti & C Abell
Nature Rev., Drug Discovery 2002, 1, 45-54.
DOI:10.1038/nrd706
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2001

100. Substrate deactivation of phenylalanine-sensitive 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase by erythrose 4-phosphate.
E J Parker, E M M Bulloch, G B Jameson & C Abell
Biochemistry 2001, 40, 14821-14828.
DOI:10.1021/bi010928j
PDF
99. Crystal structure of Escherichia coli ketopantoate reductase at 1.7 Ĺ resolution and insight into the enzyme mechanism.
D Matak-Vinkovic, M Vinkovic, S A Saldanha, J L Ashurst, F von Delft, T Inoue, R Nunez Miguel, A G Smith, T L Blundell & C Abell
Biochemistry 2001, 40, 14493-14500.
DOI:10.1021/bi011020w
PDF
98. Identification of Tyr58 as the proton donor in the aspartate-α-decarboxylase reaction.
S A Saldanha, L M Birch, M E Webb, B K Nabbs, F von Delft, A G Smith & C Abell
Chem. Commun. 2001, 18, 1760-1761.
DOI:10.1039/b106090m
PDF
97. Direct and sensitive detection of a human virus by rupture event scanning.
M A Cooper, F N Dultsev, T Minson, V P Ostanin, C Abell & D Klenerman
Nature Biotech 2001, 19, 833-837.
DOI:10.1038/nbt0901-833
PDF
96. Direct and quantitative detection of bacteriophage by "hearing" surface detachment using a quartz crystal microbalance.
F N Dultsev, R E Speight, M T Fiorini, J E Blackburn, C Abell, V P Ostanin & D Klenerman
Anal. Chem. 2001, 73, 3953-3939.
DOI:10.1021/ac0100897
PDF
95. Novel chemical tagging method for combinatorial synthesis utilizing Suzuki chemistry and fourier transform ion cyclotron resonance mass spectrometry.
M H Todd & C Abell
J. Combi. Chem. 2001, 3, 319-327.
DOI:10.1021/cc000112m
PDF
94. The crystal structure of E. coli pantothenate synthetase confirms it as a new member of the cytidylytransferase superfamily.
F von Delft, A Lewendon, V Dhanaraj, T L Blundell, C Abell & A G Smith
Structure 2001, 9, 439-450.
DOI:10.1016/S0969-2126(01)00604-9
PDF
93. Preparation of symmetrical and unsymmetrical protein-DNA conjugates using DNA as a molecular scaffold.
J M Tomkins, B K Nabbs, K Barnes, M Legido, J Blacker, R A McKendry & C Abell
ChemBioChem 2001, 5, 375-378.
DOI:10.1002/1439-7633(20010504)2:5<375::AID-CBIC375>3.0.CO;2-I
PDF
92. Chemical force microscopy with active enzymes.
R McKendry, M Fiorini, M A Cooper, T Rayment & C Abell
Biophys. J. 2001, 80, 2471-2476.
DOI:10.1016/S0006-3495(01)76215-7
PDF
91. A nondestructive technique for determining the spring constant of atomic force microscope cantilevers.
C T Gibson, B L Weeks, J R I Lee, C Abell & T Rayment
Rev. Sci. Instrum. 2001, 72, 2340-2343.
DOI:10.1063/1.1361080
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2000

90. Studies with substrate and cofactor analogues provide evidence for a radical mechanism in the chorismate synthease reaction.
A Osborne, R N F Thorneley, C Abell & S Bornemann
J. Biol. Chem. 2000, 275, 35825-35830.
DOI:10.1074/jbc.M005796200
PDF
89. The attachment and cleavage of phenols from solid supports and their single bead mass spectral analysis.
M H Todd & C Abell
Tetrahedron Lett. 2000, 8183-8187.
DOI:10.1016/S0040-4039(00)01431-3
PDF
88. Binding of vancomycin group antibiotics to D-alanine and D-Lactate presenting self-assembled monolayers.
M A Cooper, M T Fiorini, C Abell & D H Williams
Biorg. Med. Chem. 2000, 8, 2609-2616.
DOI:10.1016/S0968-0896(00)00184-X
PDF
87. A secondary β deuterium kinetic isotope effect in the chorismate synthase reaction.
S Bornemann, M-E Theoclitou, M Brune, M R Webb, R N F Thorneley & C Abell
Bioorg. Chem. 2000, 28, 191-204.
DOI:10.1006/bioo.2000.1174
PDF
86. Reductive cleavage of N-O bonds using samarium (II) iodide in a traceless release strategy for solid phase synthesis.
R M Myers, S P Langston, S P Conway & C Abell
Org. Lett. 2000, 2, 1349-1352.
DOI:10.1021/ol0055162
PDF
85. Irreversible inhibition of type I dehydroquinase by substrates for type II dehydroquinase.
J M Harris, C González Bello, M K Manthey, J R Coggins & C Abell
BioMed. Chem. Letts. 2000, 10, 407-409.
DOI:10.1016/S0960-894X(00)00057-3
84. Mechanistic studies on type I and type II dehydroquinases with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids.
E J Parker, C González Bello, J R Coggins, A R Hawkins & C Abell
Bioorg. Med. Chem. Letts. 2000, 10, 231-234.
DOI:10.1016/S0960-894X(99)00660-5
83. Palladium-catalysed carbon-carbon bond formation on solid supports.
M H Todd & C Abell
In "Solid-Phase Organic Synthesis" Ed. K. Burgess, Wiley, 2000, pp.25-79.
ISBN 978-0-47131-825-5
DOI: 10.1002/0471228249.ch2
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Pre 2000

82. A novel safety-catch linker for the solid-phase synthesis of amides and esters.
M H Todd, S F Oliver & C Abell
Org. Lett. 1999, 1, 1149-1151.
DOI:10.1021/ol990785h
PDF
81. Use of quinic acid as template in solid-phase combinatorial synthesis.
C W Phoon & C Abell
J. Combinatorial Chem. 1999, 1, 485-492.
DOI:10.1021/cc990027i
PDF
80. How much chemistry is there in chemical force microscopy?
R McKendry, M-E Theoclitou, C Abell & T Rayment
Jap. J. Appl. Phys. 1999, 38, 3901-3907.
DOI:10.1143/JJAP.38.3901
PDF
79. The final step of pantothenate biosynthesis in higher plants: cloning and characterisation of pantothenate synthetase from Lotus japonicus and Oryza sativum (Rice).
U Genschel, C A Powell, C Abell & A G Smith
Biochem. J. 1999, 341, 669-678.
PDF
78. Combinatorial synthetic design.
S Oliver & C Abell
Curr. Op. Chem. Biol. 1999, 3, 299-306.
DOI:10.1016/S1367-5931(99)80046-5
PDF
77. Adventures with atomic force microscopy.
C Abell, R McKendry & T Rayment
In "Bioorganic Chemistry: Highlights and New Aspects" Ed. U Diederichsen, T K lindhorst, B Westermann & L Wessjohann, Wiley-VCH, 1999, pp 358-364.
ISBN: 3527296654
76. Selective inhibition of type II dehydroquinases.
M Frederickson, E J Parker, A R Hawkins, J R Coggins & C Abell
J. Org. Chem. 1999, 64, 2612-2613.
DOI:10.1021/jo990004q
PDF
75. Synthesis of 4-deoxyquinic, 4-deoxyshikimate and 4-deoxy-3-dehydroshikimic acids.
C González Bello, A R Hawkins, J R Coggins & C Abell
J. Chem. Soc., Perkin Trans. I 1999, 849-854.
PDF
74. Enzymology and molecular biology of the shikimate pathway.
C Abell
In "Comprehensive Natural Products Chemistry - Vol. 1", ed. U Sankawa, 1999, Elsevier, Amsterdam, pp 573-607.
ISBN: 0080431534 (v.1)
73. A decarboxylative traceless linker approach for the solid phase synthesis of quinazolines.
J M Cobb, M T Fiorini, C R Goddard, M-E Theoclitou & C Abell
Tetrahedron Lett. 1999, 1045-1048.
DOI:10.1016/S0040-4039(99)80108-7
PDF
72. The use of trichloroacetimidate-activated resin for ester formation.
C W Phoon, S Oliver & C Abell
Tetrahedron Lett. 1998, 7959-7962.
DOI:10.1016/S0040-4039(98)01729-8
PDF
71. Enzymes that exploit imines - one way or the other.
C Abell
Biochem. Soc. Trans. 1998, 26, 310-315.
PDF
70. Comparative study of the protection of modified and unmodified dsDNA by cationic and non-cationic lipids and liposomes to digestion by DNase I.
M Legido & C Abell
J. Chem. Soc., Perkin Trans. 2 1998, 1283-1285.
PDF
69. Crystal structure of aspartate decarboxylase at 2.2 Ĺ resolution provides evidence for an ester in protein self-processing.
A Albert, V Dhanaraj, U Genschel, G Khan, M K Ramjee, R Pulido, B L Sibanda, F von Delft, M Witty, T L Blundell, A G Smith & C Abell
Nature Structural Biology 1998, 5, 289-293.
DOI:10.1038/nsb0498-289
PDF
68. The role of surface perfection in chemical force microscopy.
R McKendry, M-E Theoclitou, C Abell & T Rayment
Langmuir 1988, 14, 2846-2849.
DOI:10.1021/la970374e
PDF
67. Solid phase aldol and conjugate addition reactions using the Evans' oxazolidinone chiral auxiliary.
C W Phoon & C Abell
Tetrahedron Lett. 1998, 2655-2658.
DOI:10.1016/S0040-4039(98)00230-5
PDF
66. Synthesis of 2-bromo- and 2-fluoro-3-dehydroshikimic acids and 2-bromo- and 2-fluoroshikimic acids using synthetic and enzymatic approaches.
C González Bello, M K Manthey, J H Harris, A R Hawkins, J R Coggins & C Abell
J. Org. Chem. 1998, 63, 1591-1597.
DOI:10.1021/jo971858i
PDF
65. Chiral discrimination by chemical force microscopy.
M-E Theoclitou, R McKendry, T Rayment & C Abell
Nature 1998, 361, 566-568.
DOI:10.1038/35339
PDF
64. Solution phase synthesis of 2,6,9-trisubstituted purines.
M Fiorini & C Abell
Tetrahedron Lett. 1998, 1827-1830.
DOI:10.1016/S0040-4039(98)00098-7
PDF
63. Derailing dehydroquinate synthase by introducing a stabilising stereoelectronic effect in a reaction intermediate.
E J Parker, J R Coggins & C Abell
J. Org. Chem. 1997, 62, 8582-8585.
DOI:10.1021/jo9713060
PDF
62. Studies on the synthesis, characterisation and reactivity of aromatic diboronic acids.
M H Todd, S Balasubramanian & C Abell
Tetrahedron Lett. 1997, 6781-6784.
DOI:10.1016/S0040-4039(97)01552-9
PDF
61. A combinatorial approach to identifying protein tyrosine phosphatase substrates from a phosphotyrosine peptide library.
Y W Cheung, C Abell & S Balasubramanian
J. Am. Chem. Soc. 1997, 119, 9568-9569.
DOI:10.1021/ja971825k
PDF
60. Synthesis of 2-oxindole derivatives via the intramolecular Heck reaction on solid support.
V Arumugam, A Routledge, C Abell & S Balasubramanian
Tetrahedron Lett. 1997, 6437-6476.
DOI:10.1016/S0040-4039(97)01481-0
PDF
59. Synthesis of tetrahydroquinolines, hexahydrobenzoindolizines and an aryl phosphonate linker for the generation of catalytic antibodies.
C González Bello, C Abell & F J Leeper
J. Chem. Soc., Perkin Trans. 1 1997, 1017-1024.
DOI:10.1039/A606968A
PDF
58. E. coli L-aspartate-alpha-decarboxylase: preprotein processing and observation of reaction intermediates by mass spectrometry.
M K Ramjee, U Genschel, C Abell & A G Smith
Biochem. J. 1997, 323, 661-669.
PDF
57. Synthesis of (2R)-2-bromodehydroquinic acid and (2R)-2-fluorodehydroquinic acid.
M K Manthey, C González Bello & C Abell
J. Chem. Soc. Perkin Trans. 1 1997, 625-628.
DOI:10.1039/A606104D
PDF
56. The use of a dithiane protected benzoin photolabile safety catch linker for solid phase synthesis.
A Routledge, C Abell & S Balasubramanian
Tetrahedron Lett. 1997, 1227-1230.
DOI:10.1016/S0040-4039(96)02478-1
PDF
55. Lipophilic modification of oligonucleotides.
J M Tomkins, K J Barnes, A J Blacker, W J Watkins & C Abell
Tetrahedron Lett. 1997, 38, 691-694.
DOI:10.1016/S0040-4039(96)02394-5
PDF
54. An investigation into solid-phase radical chemistry - synthesis of furan rings.
A Routledge, C Abell & S Balasubramanian
Synlett. 1997, 61-62.
DOI:10.1055/s-1997-704
PDF
53. Approaches to antibody-catalysed cationic cyclisations: chemical studies of leaving groups and cyclisation modes.
C Lawrence, I M Bell, C Abell & F J Leeper
Israeli J. Chem. 1996, 36, 161-169.
52. Evidence from kinetic isotope studies for an enolate intermediate in the mechanism of type II dehydroquinases.
J M Harris, C González Bello, C Kleanthous, A R Hawkins, J R Coggins & C Abell
Biochem. J. 1996, 319, 333-336.
PDF
51. Comparison of the substrate specificity of type I and type II dehydroquinases with 5-deoxy- and 4,5-dideoxydehydroquinic acid.
J M Harris, W J Watkins, A R Hawkins, J R Coggins & C Abell
J. Chem. Soc., Perkin Trans. I 1996, 2371-2377.
DOI:10.1039/p19960002371
PDF
50. An electrochemical study to model the chorismate synthase reaction.
M-E Theoclitou, P J Duggan & C Abell
Bioorg. & Med. Chem. Lett. 1996, 6, 1285-1288.
DOI:10.1016/0960-894X(96)00217-X
PDF
49. Enzymatic synthesis of (6R)- and (6S)-fluoroshikimic acids.
P J Duggan, E Parker, J R Coggins & C Abell
Bioorg. & Med. Chem. Lett. 1995, 5, 2347-2352.
DOI:10.1016/0960-894X(95)00405-I
PDF
48. Escherichia coli chorismate synthase catalyses the conversion of (6S)-6-fluoro-5-enolpyruvylshikimate-3-phosphate to 6-fluorochorismate.
S Bornemann, M K Ramjee, S Balasubramanian, C Abell, J R Coggins, D J Lowe & R N F Thorneley
J. Biol. Chem. 1995, 270, 22811-22815.
DOI:10.1074/jbc.270.39.22811
PDF
47. Escherichia coli chorismate synthase: a deuterium kinetic isotope effect under single turnover and steady state conditions shows that a flavin intermediate forms before the C-(6proR)-H bond is cleaved.
S Bornemann, S Balasubramanian, J R Coggins, C Abell, D J Lowe & R N F Thorneley
Biochem. J. 1995, 305, 707-710.
PDF
46. Escherichia coli dihydrodipicolinate synthase: characterisation of the imine intermediate and the product of bromopyruvate treatment by electrospray mass spectrometry.
E B Borthwick, S J Connell, D W Tudor, D J Robins, A Shneier, C Abell & J R Coggins
Biochem. J. 1995, 305, 521-524.
PDF
45. Observation of a secondary tritium isotope effect in the chorismate synthase reaction.
S Balasubramanian, J R Coggins & C Abell
Biochemistry 1995, 34, 341-348.
DOI:10.1021/bi00001a042
PDF
44. The resolution of diterpene cyclase activities from Ricinus Communis.
C Spickett , K Ponnamperuma, & C Abell
Phytochemistry 1994, 37, 971-973.
DOI:10.1016/S0031-9422(00)89511-4
PDF
43. Design and synthesis of transition state analogues for a cationic cyclisation.
I M Bell, C Abell & F J Leeper
J. Chem. Soc., Perkin Trans. 1 1994, 1997-2006.
42. Tandem overproduction and characterisation of the nuclease domain of colicin E9 and its cognate inhibitor protein Im9.
R Wallis, A Reilly, K Barnes, C Abell, D G Campbell, G R Moore, R James & C Kleanthous
Eur. J. Biochem. 1994, 220, 447-454.
DOI:10.1111/j.1432-1033.1994.tb18642.x
PDF
41. Evidence for the pathway to pantothenate in plants.
C E Jones, J E Dancer, A G Smith & C Abell
Can. J. Chem. 1994, 72, 261-263.
DOI:10.1139/v94-039
PDF
40. Studies on Escherichia coli chorismate synthase.
S Bornemann, M N Manjee, D J Lowe, R N F Thorneley, J R Coggins, C Abell, S Balasubramanian, T R Hawkes, W W Nichols & G M Davies
Proceedings of the Eleventh International Symposium on Flavins and Flavoproteins, Walter de Gruyter & Co., Berlin 1994.
ISBN 978-3110141658
pp843-846
39. Different mechanistic and stereochemical courses for the reactions catalysed by type I and type II dehydroquinases.
J Harris, C Kleanthous, J R Coggins, A R Hawkins & C Abell
J. Chem. Soc., Chem. Commun. 1993, 1080-1081.
DOI:10.1039/C39930001080
PDF
38. Evidence for opposite stereochemical courses for the reactions catalysed by type I and type II dehydroquinases.
A Shneier, J Harris, C Kleanthous, J R Coggins, A R Hawkins & C Abell
BioMed. Chem. Lett. 1993, 3, 1399-1402.
DOI:10.1016/S0960-894X(01)80419-4
PDF
37. Cloning and sequencing of the E. coli panB gene, encoding ketopantoate hydroxymethyltransferase, and overexpression of the enzyme.
C E Jones, J M Brook, D Buck, C Abell & A G Smith
J. Bacteriol. 1993, 175, 2125-2130.
36. Purification, characterisation, crystallisation and x-ray analysis of selenomethionine-labelled hydroxymethylbilane synthase from Escherichia coli.
A Hadener, P K Matzinger, V N Malashkevich, G V Louie, S P Wood, P Oliver, P R Alefounder, A R Pitt, C Abell & A R Battersby
Eur. J. Biochem. 1993, 211, 615-624.
DOI:10.111/j.1432-1033.1993.tb17589.x
PDF
35. Enzymatic formation of lactams on organic solvents.
A L Gutman, E Meyer, X Yue & C Abell
Tetrahedron Lett. 1992, 33, 3943-3946.
DOI:10.1016/S0040-4039(00)74825-8
PDF
34. Reaction of (6R)-6-F-EPSP with recombinant Escherichia coli chorismate synthase generates a stable flavin mononucleotide semiquinone radical.
M N Ramjee, S Balasubramanian, C Abell, J R Coggins, G M Davies, T R Hawkes, D J Lowe, & R N F Thorneley
J. Am. Chem. Soc. 1992, 114, 3151-3153.
DOI:10.1021/ja00034a079
PDF
33. Post-translational modification of Klebsiella pneumoniae flavodoxin by covalent attachment of coenzyme A shown by 31P NMR and electrospray mass spectrometry, prevents electron transfer from the nifJ protein to nitrogenase. A possible new regulatory mechanism for biological nitrogen fixation.
R N F Thorneley, C Abell, G A Ashby, M H Drummond, R R Eady, S Huff, C J Macdonald & A Shneier
Biochemistry 1992, 31, 1216-1244.
DOI:10.1021/bi00119a035
PDF
32. Observation of an imine intermediate in the dehydroquinase reaction by electrospray mass spectrometry.
A Shneier, C Kleanthous, R Deka, J R Coggins & C Abell
J. Am. Chem. Soc. 1991, 113, 9416-9418.
DOI:10.1021/ja00024a085
PDF
31. Inhibition of chorismate synthase by (6R)- and (6S)-6-fluoro-5-enolpyruvylshimate 3-phosphate.
S Balsubramanian, G M Davies, J R Coggins & C Abell
J. Am. Chem. Soc. 1991, 113, 8945-8946.
DOI:10.1021/ja00023a051
PDF
30. Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition-elimination reactions.
D E Cane, C Abell, P H M Harrison, B R Hubbard, C T Kane, R Lattman, J S Oliver & S W Weiner
Phil. Trans. Roy. Soc., London Series B Biol. Sci. 1991, 332, 123-129.
29. Uroporphyrinogen III synthase: studies on its mechanism of action, molecular biology, and biochemistry.
N C Crockett, P R Alefounder, A R Battersby & C Abell
Tetrahedron 1991, 47, 6003-6014.
DOI:10.1016/S0040-4020(01)86492-9
PDF
28. An amino acid sequence motif observed amongst enzymes of the shikimate pathway.
T D H Bugg, P R Alefounder & C Abell
Biochem. J. 1991, 276, 841-843.
PDF
27. Studies on the mechanism of hydroxymethylbilane synthase concerning the role of arginines in substrate binding.
M Lander, A R Pitt, P R Alefounder, C Abell & A R Battersby
Biochem. J. 1991, 275, 447-452.
PDF
26. Synthesis of [6-2H]enolpyruvylshikimate-3-phosphate.
S Balasubramanian & C Abell
Tetrahedron Lett. 1991, 963-966.
DOI:10.1016/S0040-4039(00)92131-2
PDF
25. Observation of an isotope effect in the chorismate synthase reaction.
S Balasubramanian, C Abell & J R Coggins
J. Am. Chem. Soc. 1990, 112, 8581-8583.
DOI:10.1021/ja00179a052
PDF
24. Biosynthesis of pentalenene and pentalenolactone.
D E Cane, J S Oliver, P H M Harrison, C Abell, B R Hubbard, C T Kane & R Lattman
J. Am. Chem. Soc. 1990, 112, 4513-4524.
DOI:10.1021/ja00167a059
PDF
23. Investigation of putative active site lysine residues in hydroxymethylbilane synthase: preparation and characterisation of mutants in which (a) Lys-55, (b) Lys-59 and (c) both Lys-55 and 59 have been replaced by glutamine.
A Hädener, P R Alefounder, G J Hart, C Abell & A R Battersby
Biochem. J. 1990, 271, 487-491.
22. Isolation and characterisation of a cDNA clone for a chlorophyll synthesis enzyme from Euglena gracilis.
A L Sharif, A G Smith & C Abell
Eur. J. Biochem 1989, 184, 353-359.
DOI:10.1111/j.1432-1033.1989.tb15026.x
PDF
21. Evidence that the pyridoxal phosphate modification of lysine residues (Lys-55 and Lys-59) causes inactivation of hydroxymethylbilane synthase (porphobilinogen deaminase).
A D Miller, L C Packman, G J Hart, P R Alefounder, C Abell & A R Battersby
Biochem. J. 1989, 262, 119-124.
20. Biosynthesis of the pigments of life: structure and mode of action of a novel enzymatic cofactor.
P R Alefounder, G J Hart, A D Miller, U Beifuss, C Abell, F J Leeper & A R Battersby
Bioorg. Chem. 1989, 17, 121-129.
DOI:10.1016/0045-2068(89)90013-8
PDF
19. Affinity labelling of E. coli dehydroquinase.
T D H Bugg, C Abell, & J R Coggins
Tetrahedron Lett. 1988, 6783-6786.
DOI:10.1016/S0040-4039(00)82454-5
PDF
18. Specificity of E. coli shikimate dehydrogenase towards analogues of 3-dehydroshikimic acid.
T D H Bugg, C Abell & J R Coggins
Tetrahedron Lett. 1988, 6779-6782.
DOI:10.1016/S0040-4039(00)82453-3
PDF
17. The absolute stereochemistry of the enzymic cyclisation to form the sterpurene sesquiterpenes.
C Abell & A P Leech
Tetrahedron Lett. 1988, 4337-4340.
DOI:10.1016/S0040-4039(00)80491-8
PDF
16. The sequence of hemC, hemD and two additional E. coli genes.
P R Alefounder, C Abell & A R Battersby
Nucl. Acids Res. 1988, 16, 9871.
DOI:10.1093/nar/16.20.9871
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15. Pentalenene biosynthesis and the enzymatic cyclisation of farnesyl pyrophosphate. Anti stereochemistry in a biological SE' reaction.
D E Cane, C Abell, R Lattman, C T Kane, B R Hubbard & P R Harrison
J. Am. Chem. Soc. 1988, 110, 4081-4082.
DOI:10.1021/ja00220a081
PDF
14. The absolute configuration of the sterpurene sesquiterpenes.
C Abell & A P Leech
Tetrahedron Lett. 1988, 1985-1986.
DOI:10.1016/S0040-4039(00)82096-1
PDF
13. Structure of (-)-3-dehydroshikimic acid monohydrate.
C Abell, F H Allen, T D H Bugg, M J Doyle & P R Raithby
Acta Cryst. 1988, C44, 1290-1292.
DOI:10.1107/S0108270188002896
PDF
12. Structure of (-)-quinic acid.
C Abell, F H Allen, T D H Bugg, M J Doyle & P R Raithby
Acta Cryst. 1988, C44, 1287-1290.
DOI:10.1107/S0108270188002884
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11. Structure of sodium (-)-shikimate dihydrate.
C Abell, F H Allen, T D H Bugg, M J Doyle & P R Raithby
Acta Cryst. 1988, C44, 1204-1207.
DOI:10.1107/S0108270188002872
PDF
10. Evidence for consecutive 1,2-alkyl shifts in sterpurene biosynthesis: isolation and characterisation of 7,12-dihydroxysterpurene.
C Abell & A P Leech
Tetrahedron Lett. 1987, 4887-4890.
DOI:10.1016/S0040-4039(00)96652-8
PDF
9. Studies on the biosynthesis of hydroxymellein using 17O NMR and 2H NMR spectroscopy to determine the origin of the C-4 hydroxyl group.
C Abell, A C Sutkowski,& J Staunton
J. Chem. Soc., Chem. Commun. 1987, 586-587.
DOI:10.1039/C39870000586
PDF
8. Purification, N-terminal amino acid sequence and properties of hydroxymethylbilane synthase (porphobilinogen deaminase) from Escherichia coli.
G J Hart, C Abell & A R Battersby
Biochem. J. 1986, 240, 273-276.
PDF
7. "The use of NMR spectroscopy to follow deuterium in studies of fungal metabolism" in "Modern Methods of Plant Analysis" Vol. 2, ed. H F Linskens & J F Jackson, Springer-Verlag, Berlin, 1986.
ISBN: 354015910x
pp60-89
6. Biomimetic syntheses of the heptaketide fungal metabolites alternariol and rubrofusarin: models for cyclisation reactions catalysed by polyketide synthase enzymes.
C Abell, B Bush & J Staunton
J. Chem. Soc., Chem. Commun. 1986, 15-17.
DOI:10.1039/C39860000015
PDF
5. Pentalenene biosynthesis and the enzymatic cyclisation of farnesyl pyrophosphate: proof that the cyclisation is catalysed by a single enzyme.
D E Cane, C Abell & A M Tillman
Bioorganic Chemistry 1984, 12, 312-328.
DOI:10.1016/0045-2068(84)90013-0
PDF
4. Biosynthesis of 6-methylsalicylic acid: the combined use of mono- and trideuteriated acetate precursors to investigate the degree of stereocontrol in the aromatisation sequence.
C Abell & J Staunton
J. Chem. Soc., Chem. Commun. 1984, 1005-1007.
DOI:10.1039/C39840001005
PDF
3. Biosynthesis of the polyketide mellein from CD3CO2H and 13CD3CO2H in Aspergillus melleus: detection of deuterium by 2H NMR and edited 13C NMR spectra.
C Abell, D M Doddrell, M J Garson, E D Laue & J Staunton
J. Chem. Soc., Chem. Commun. 1983, 694-696.
DOI:10.1039/C39830000694
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2. Biosynthesis of the fungal metabolites alternariol, mellein, rubrofusarin, and 6-methylsalicylic acid from CD3CO2H.
C Abell, M J Garson, F J Leeper & J Staunton
J. Chem. Soc., Chem. Commun. 1982, 1011-1013.
DOI:10.1039/C39820001011
PDF
1. The use of 2H NMR spectroscopy and β-isotopic shifts in the 13C NMR spectrum to measure deuterium retention in the biosynthesis of the polyketide 6-methylsalicylic acid.
C Abell & J Staunton
J. Chem. Soc., Chem. Commun. 1981, 856-858.
DOI:10.1039/C39810000856
PDF

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