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Publication List

Last updated May 2018


2018

311. Droplet-based microfluidic analysis and screening of single plant cells
Z Yu, CR Boehm, JM Hibberd, C Abell, J Haseloff, SJ Burgess and I Reyna-Llorens
PLoS ONE 2018, 13, e0196810
DOI: 10.1371/journal.pone.0196810
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310. Fragment-based approach to targeting inosine-5'-monophosphate dehydrogenase (IMPDH) from Mycobacterium tuberculosis
A Trapero, A Pacitto, V Singh, M Sabbah, AG Coyne, V Mizrahi, TL Blundell, DB Ascher and C Abell
J Med Chem 2018, 61, 2806-2822
DOI: 10.1021/acs.jmedchem.7b01622
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309. Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles
S Abalde-Cela, P Taladriz-Blanco, MG de Oliveira and C Abell
Sci Rep 2018, 8, 2440
DOI: 10.1038/s41598-018-20754-x
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308. Supramolecular nested microbeads as building blocks for macroscopic self-healing scaffolds
Z Yu, J Liu, CSY Tan, OA Scherman and C Abell
Angew Chem Int Ed Engl 2018, 61, 465-473
DOI: 10.1002/anie.201711522
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2017

307. Mass spectrometry for fragment screening
DSH Chan, AJ Whitehouse, AG Coyne and C Abell
Essays Biochem 2017, 61, 465-473
DOI: 10.1042/EBC20170071
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306. Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach
G Mugumbate, V Mendes, M Blaszczyk, M Sabbah, G Papadatos, J Lelievre, L Ballell, D Barros, C Abell, TL Blundell and JP Overington
Front Pharmacol 2017, 8, 681
DOI: 10.3389/fphar.2017.00681
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305. Effect of DMSO on Protein Structure and Interactions Assessed by Collision-Induced Dissociation and Unfolding
DSH Chan, ME Kavanagh, KJ McLean, AW Munro, D Matak-Vinković, AG Coyne and C Abell
Anal Chem 2017, 89, 9976-9983
DOI: 10.1021/acs.analchem.7b02329
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304. Bioinspired supramolecular fibers drawn from a multiphase self-assembled hydrogel
Y Wu, DU Shah, C Liu, Z Yu, J Liu, X Ren, MJ Rowland, C Abell, MH Ramage and OA Sherman
Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 8163-8169
DOI: 10.1073/pnas.1705380114
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303. Fragment screening against the EthR-DNA interaction by native mass spectrometry
DSH Chan, V Mendes, SE Thomas, BN McConnell, D Matak-Vinković, AG Coyne, TL Blundell and C Abell
Angew. Chem. Int. Ed. 2017, 56, 7488-7491
DOI: 10.1002/anie.201702888
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302. Tough supramolecular polymer networks with extreme stretchability and fast room-temperature self-healing
J Liu, CSY Tan, Z Yu, N Li, C Abell and OA Sherman
Adv Mater 2017, 29, 1605325
DOI: 10.1002/adma.201605325
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301. Fragment-sized EthR inhibitors exhibit exceptionally strong ethionamide boosting effect in whole-cell Mycobacterium tuberculosis assays
PO Nikiforov, M Blaszczyk, S Surade, HI Boshoff, A Sajid, V Delorme, N Deboosere, P Brodin, AR Baulard, CE Barry, TL Blundell and C Abell
ACS Chem Biol 2017, 12, 1390-1396
DOI: 10.1021/acschembio.7b00091
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300. The biochemical properties of the two Arabidopsis thaliana isochorismate synthases
KM Macaulay, GA Heath, A Ciulli, AM Murphy, C Abell, JP Carr and AG Smith
Biochem J 2017, 474, 1579-1590
DOI: 10.1042/BCJ20161069
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299. Structural insights into the EthR-DNA interaction using native mass spectrometry
DSH Chan, W-G Seetoh, BN McConnell, D Matak-Vinković, SE Thomas, V Mendes, M Claszczyk, AG Coyne, TL Blundell and C Abell
Chem. Commun. 2017, 53, 3527-3530
DOI: 10.1039/C7CC00804J
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298. Surface mediated cooperative interactions of drugs enhance mechanical forces for antibiotic action
JW Ndieyira, J Bailey, SB Patil, M Vögtli, MA Cooper, C Abell, RA McKendry and G Aeppli
Scientific Reports 2017, 7, 41206
DOI: 10.1038/srep41206
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297. Fragment profiling approach to inhibitors of the orphan M. tuberculosis P450 CYP144A1
ME Kavanagh, J Chenge, A Zoufir, KJ McLean, AG Coyne, A Bender, AW Munro and C Abell
Biochemistry 2017, 56, 1559-1572
DOI: 10.1021/acs.biochem.6b00954
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296. Biomimetic supramolecular polymer networks exhibiting both toughness and self-recovery
J Liu, CSY Tan, Z Yu, Y Lan, C Abell and OA Scherman
Adv Mater 2017, 29, 1604951
DOI: 10.1002/adma.201604951
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295. Cucurbit[n]uril-based microcapsules self-assembled within microfluidic droplets: a versatile approach for supramolecular architectures and materials
J Liu, Y Lan, Z Yu, CSY Tan, RM Parker, C Abell and OA Scherman
Acc Chem Res 2017, 50, 208-217
DOI: 10.1021/acs.accounts.6b00429
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294. Aqueous interfacial gels assembled from small molecule supramolecular polymers
AS Groombridge, A Palma, RM Parker, C Abell and OA Scherman
Chem. Sci 2017, 8, 1350-1355
DOI: 10.1039/c6sc04103e
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293. Structural characterization and ligand/inhibitor identification provide functional insights into the Mycobacterium tuberculosis cytochrome P450 CYP126A1
JT Chenge, DV Le, S Swami, KJ McLean, ME Kavanagh, AG Coyne, SEJ Rigby, MR Cheesman, HM Girvan, CW Levy, B Rupp, JP von Kries, C Abell, D Leys and AW Munro
J Biol Chem 2017, 292, 1310-1329
DOI: 10.1074/jbc.M116.748822
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2016

292. Insight into protein conformation and subcharging by DMSO from native ion mobility mass spectrometry
DSH Chan, D Matak-Vinković, AG Coyne and C Abell
ChemistrySelect 2016, 1, 5686-5690
DOI: 10.1002/slct.201601402
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291. Fragment-based approaches to TB drugs
C Marchetti, DSH Chan, AG Coyne and C Abell
Parasitology 2016, 1-12
DOI: 10.1017/S0031182016001876
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290. Disrupting the constitutive, homodimeric protein-protein interface in CK2β using a biophysical fragment-based approach
W-G Seetoh and C Abell
J Am Chem Soc 2016, 138, 14303-14311
DOI: 10.1021/jacs.6b07440
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289. Label-free analysis and sorting of microalgae and cyanobacteria in microdroplets by intrinsic chlorophyll fluorescence for the identification of fast growing strains
RJ Best, JJ Lyczakowski, S Abalde-Cela, Z Yu, C Abell and AG Smith
Anal Chem 2016, 88, 10445-10451
DOI: 10.1021/acs.analchem.6b02364
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288. Microcapsule buckling triggered by compression-induced interfacial phase change
AR Salmon, RM Parker, AS Groombridge, A Maestro, RJ Coulston, J Hegemann, J Kierfeld, OA Scherman and C Abell
Langmuir 2016, 32, 10987-10994
DOI: 10.1021/acs.langmuir.6b03011
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287. Dual-responsive supramolecular colloidal microcapsules from cucurbit[8]uril molecular recognition in microfluidic droplets
Z Yu, Y Lan, RM Parker, W Zhang, X Deng, OA Scherman and C Abell
Polymer Chemistry 2016, 7, 5996
DOI: 10.1039/c6py01171c
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286. Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51
T Moschetti, T Sharpe, G Fischer, ME Marsh, H Ng, M Morgan, D Scott, TL Blundell, A Venkitaraman, J Skidmore, C Abell and M Hyvönen
J Mol Biol 2016, 428, 4589-4606
DOI: 10.1016/j.jmb.2016.10.009
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285. Hierarchical self-assembly of cellulose nanocrystals in a confined geometry
RM Parker, B Frka-Petesic, G Guidetti, G Kamita, G Consani, C Abell and S Vignolini
ACS Nano 2016, 10, 8443-8449
DOI: 10.1021/acsnano.6b03355
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284. Substrate fragmentation for the design of M. tuberculosis CYP121 inhibitors
ME Kavanagh, JL Gray, SH Gilbert, AG Coyne, KJ McLean, HJ Davis, AW Munro and C Abell
ChemMedChem 2016, 11, 1924-1935
DOI: 10.1002/cmdc.201600248
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This article is corrected by:
Corrigendum in ChemMedChem 2017, 12, 194-195
DOI: 10.1002/cmdc.201600619
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283. Inhibition of Ral GTPases using a stapled peptide approach
JC Thomas, JM Cooper, NS Clayton, C Wang, MA White, C Abell, D Owen and HR Mott
J Biol Chem 2016, 291, 18310-18325
DOI: 10.1074/jbc.M116.720243
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282. Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site
M Kasbekar, G Fischer, BT Mott, A Yasgar, M Hyvönen, HI Boshoff, C Abell, CE Barry and CJ Thomas
Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 7503-7508
DOI: 10.1073/pnas.1600630113
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281. Specific inhibition of CK2α from an anchor outside the active site
P Brear, C De Fusco, K Hadje Georgiou, NJ Francis-Newton, CJ Stubbs, HF Sore, AR Venkitaraman, C Abell, DR Spring and M Hyvönen
Chem Sci 2016, 7, 6839-6845
DOI: 10.1039/c6sc02335e
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280. Spirooxindoles as novel 3D-fragment scaffolds: synthesis and screening against CYP121 from M. tuberculosis
HJ Davis, ME Kavanagh, T Balan, C Abell and AG Coyne
Bioorg Med Chem Lett 2016, 26, 3735-3740
DOI: 10.1016/j.bmcl.2016.05.073
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279. Small molecules, big targets: drug discovery faces the protein-protein interaction challenge
DE Scott, AR Bayly, C Abell and J Skidmore
Nat Rev Drug Discov 2016, 15, 533-550
DOI: 10.1038/nrd.2016.29
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278. Mass spectrometry reveals protein kinase CK2 high-order oligomerization via the circular and linear assembly
W-G Seetoh, DS Chan, D Matak-Vinković and C Abell
ACS Chem Biol, 2016, 11, 1151-1517
DOI: 10.1021/acschembio.6b00064
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277. Microfluidic droplet-facilitated hierarchical assembly for dual cargo loading and synergistic delivery
Z Yu, Y Zheng, RM Parker, Y Lan, Y Wu, RJ Coulston, J Zhang, OA Scherman and C Abell
ACS Appl Mater Interfaces, 2016, 8, 8811-8820
DOI: 10.1021/acsami.6b00661
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276. Fragment-based approaches to the development of Mycobacterium tuberculosis CYP121 Inhibitors
ME Kavanagh, AG Coyne, KJ McLean, GG James, CW Levy, LB Marino, LP de Carvalho, DS Chan, SA Hudson, S Surade, D Leys, AW Munro and C Abell
J Med Chem, 2016, 59, 3272-3302
DOI: 10.1021/acs.jmedchem.6b00007
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275. Structure activity relationship of the peptide binding motif mediating the RAD51:BRCA2 protein-protein interaction
DE Scott, M Marsh, TL Blundell, C Abell and M Hyvönen
FEBS letters, 2016, 590, 1094-1102
DOI: 10.1002/1873-3468.12139
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274. ATP half-sites in RadA and RAD51 recombinases bind nucleotides
ME Marsh, DE Scott, MT Ehebauer, C Abell, TL Blundell and M Hyvönen
FEBS Open Bio, 2016, 6, 372-385
DOI: 10.1002/2211-5463.12052
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273. Monitoring early-stage nanoparticle assembly in microdroplets by optical spectroscopy and SERS
AR Salmon, R Esteban, RW Taylor, JT Hugall, CA Smith, G Whyte, OA Scherman, J Aizpurua, C Abell and JJ Baumberg
Small, 2016, 12, 1788-1796
DOI: 10.1002/smll.201503513
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272. A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters
PO Nikiforov, S Surade, M Blaszczyk, V Delorme, P Brodin, AR Baulard, TL Blundell and C Abell
Org Biomol Chem, 2016, 14, 2318
DOI: 10.1039/C5OB02630J
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271. Structural characterization of CYP144A1 - a cytochrome P450 enzyme expressed from alternative transcripts in Mycobacterium tuberculosis
J Chenge, ME Kavanagh, MD Driscoll, KJ McLean, DB Young, T Cortes, D D Matak-Vinković, CW Levy, SEJ Rigby, D Leys, C Abell and AW Munro
Scientific Reports, 2016, 6, 26628
DOI: 10.1038/srep26628
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270. Structure-based identification of inhibitory fragments targeting the p300/CBP-associated factor bromodomain
A Chaikuad, S Lang, PE Brennan, C Temperini, O Fedorov, J Hollander, R Nachane, C Abell, S Müller, G Siegal and S Knapp
J Med Chem, 2016, 59, 1648-1653
DOI: 10.1021/acs.jmedchem.5b01719
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269. Optimization of inhibitors of Mycobacterium tuberculosis pantothenate synthetase based on group efficiency analysis
AW Hung, HL Silvestre, S Wen, GP George, J Boland, TL Blundell, A Ciulli and C Abell
ChemMedChem, 2016, 11, 38-42
DOI: 10.1002/cmdc.201500414
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2015

268. Supracolloidal architectures self-assembled in microdroplets
X Xu, F Tian, X Liu, RM Parker, Y Wu, Z Yu, OA Sherman and C Abell
Chemistry, 2015, 21, 15516-15519
DOI: 10.1002/chem.201503194
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267. Formation of cucurbit[8]uril-based supramolecular hydrogel beads using droplet-based microfluidics
X Xu, EA Appel, X Liu, RM Parker, OA Scherman and C Abell
Biomacromolecules, 2015, 16, 2743-2749
DOI: 10.1021/acs.biomac.5b01048
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266. The application of ligand-mapping molecular dynamics simulations to the rational design of peptidic modulators of protein-protein interactions
YS Tan, DR Spring, C Abell and CS Verma
J. Chem. Theory Comput., 2015, 11(7), 3199-3210
DOI: 10.1021/ct5010577
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265. Different flavours of fragments
C Abell and C Dagostin
Fragment-based Drug Discovery, Ch. 1. RSC Drug Discovery Series No. 47, 2015,
DOI: 10.1039/9781782620938-00001
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264. Differentially addressable cavities within metal-organic cage-cross-linked polymeric hydrogels
JA Foster, RM Parker, AM Belenguer, N Kishi, S Sutton, C Abell and JR Nitschke
J. Am. Chem. Soc., 2015, 137 (30), 9722-9729
DOI: 10.1021/jacs.5b05507
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263. Supramolecular hydrogel microcapsules via cucurbit[8]uril host-guest interactions with triggered and UV-controlled molecular permeability
Z Yu, J Zhang, RJ Coulston, RM Parker, F Biedermann, X Liu, OA Scherman and C Abell
Chem. Sci, 2015, 6 (8): 4929-4933
DOI: 10.1039/C5SC01440A
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262. High-throughput detection of ethanol-producing cyanobacteria in a microdroplet platform
S Abalde-Cela, A Gould, X Liu, E Kazamia, AG Smith and C Abell
J.R. Soc Interface, 2015, 12, 20150216
DOI: 10.1098/rsif.2015.0216
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261. Surface-immobilised micelles via cucurbit[8]uril-rotaxanes for solvent-induced burst release
C Hu, Y Zheng, Z Yu, C Abell and OA Scherman
Chem. Commun., 2015, 51, 4858
DOI: 10.1039/c5cc00121h
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260. Molecular insights into the binding of coenzyme F420 to the conserved protein Rv1155 from Mycobacterium tuberculosis
EH Mashalidis, AG Gittis, A Tomczak, C Abell, CA Smith, CE Barry and DN Garboczi
Protein Science, 2015, 24, 729-740
DOI: 10.1002/pro.2645
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259. Electrostatically directed self-assembly of ultrathin supramolecular polymer microcapsules
RM Parker, J Zhang, Y Zhang, RJ Coulston, CA Smith, AR Salmon, Z Yu, OA Scherman and C Abell
Adv. Funct. Mater, 2015, 25, 4091-4100
DOI: 10.1002/adfm.201501079
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258. Selective targeting of the TPX2 Site of Importin-α using fragment-based ligand design
RS Holvey, E Valkov, D Neal, M Stewart, TL Blundell and C Abell
ChemMedChem, 2015, 10, 1232-1239
DOI: 10.1002/cmdc.201500014
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257. Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases
DE Scott, AG Coyne, AG Venkitaramen, TL Blundell, C Abell and M Hyvönen
ChemMedChem, 2015, 10 (1), 296-303
DOI: 10.1002/cmdc.201402428
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256. Design and structural analysis of aromatic inhibitors of Type II dehydroquinase from mycobacterium tuberculosis
NI Howard, MV Dias, F Peyrot, L Chen, MF Schmidt, TL Blundell and C Abell
ChemMedChem, 2015, 10 (1), 116-133
DOI: 10.1002/cmdc.201402298
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2014

255. Interfacial assembly of dendritic microcapsules with host-guest chemistry
Y Zheng, Z Yu, RM Parker, Y Wu, C Abell and OA Scherman
Nature Communications, 2014, 5, 5772
DOI: 10.1038/ncomms6772
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254. Binding hotspots of BAZ2B bromodomain: Histone interaction revealed by solution NMR driven docking
FM Ferguson, DM Dias, JP Rodrigues, H Wienk, H Boelens, AM Bonvin, C Abell and A Ciulli
Biochemistry,2014, 53 (42), 6706-6716
DOI: 10.1021/bi500909d
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253. Evolution of enzyme catalysts caged in biomimetic gel-shell beads
M Fischlechner, Y Schaerli, MF Mohamed, S Patil, C Abell and F Hollfelder
Nat Chem, 2014, 6 (9), 791-796
DOI: 10.1038/nchem.1996
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252. Regioselective conversion of arenes to N-aryl-1.2.3-triazoles using C-H borylation
R Srinivasan, AG Coyne and C Abell
Chem Eur J, 2014, 20, 11680-11684
DOI: 10.1002/chem.201403021
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251. Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy
SN Mageed, F Cunningham, AW Hung, HL Silvestre, S Wen, TL Blundell, C Abell and GA McConkey
AAC., 2014, 02640-14
DOI: 10.1128/AAC.02640-14
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250. The use of chlorobenzene as a probe molecule in molecular dynamics simulations
YS Tan, DR Spring, C Abell and C Verma
J. Chem. Inf. Model., 2014
DOI: 10.1021/ci500215x
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249. Supramolecular colloidosomes: fabrication, characterisation and triggered release of cargo
G Stephenson, RM Parker, Y Lan, Z Yu, OA Scherman and C Abell
Chem. Commun., 2014, 50, 7048-7051
DOI: 10.1039/C4CC01479K
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248. Validating fragment-based drug discovery for biological RNAs: lead fragments bind and remodel the TPP riboswitch specifically
KD Warner, P Homan, KM Weeks, AG Smith, C Abell and AR Ferré -D'Amaré
Chem Biol., 2014, 21, 591-595
DOI: 10.1016/j.chembiol.2014.03.007
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247. Threonine 57 is required for the post-translational activation of Escherichia coli aspartate α-decarboxylase
ME Webb, BA Yorke, T Kershaw, S Lovelock, CM Lobley, ML Kilkenny, AG Smith, TL Blundell, AR Pearson and C Abell
Acta Cryst., 2014, D70, 1166-1172
DOI: 10.1107/S1399004713034275
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246. Surface-stress sensors for rapid and ultrasensitive detection of active free drugs in human serum
JW Ndieyira, N Kappeler, S Logan, MA Cooper, C Abell, RA McKendry and G Aeppli
Nat Nanotechnol, 2014, 9, 225-232
DOI: 10.1038/nnano.2014.33
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245. A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR
S Surade, N Ty, N Hengrung, B Lechartier, ST Cole, C Abell and TL Blundell
Biochem J, 2014, 458, 387-394
DOI: 10.1042/BJ20131127
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244. Biofragments: an approach towards predicting protein function using biologically related fragments and its application to mycobacterium tuberculosis CYP126
SA Hudson, EH Mashalidis, A Bender, KJ McLean, AW Munro and C Abell
ChemBioChem, 2014, 5, 549-555
DOI: 10.1002/cbic.201300697
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243. Real time dual-channel multiplex SERS ultradetection
S Abalde-Cela, C Abell, RA Alvarez-Puebla and L M Liz-Marzán
J. Phys. Chem. Lett., 2014, 5, 73-79
DOI: 10.1021/jz402419k
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242. Targeting a c-MYC G-quadruplex DNA with a fragment library
HR Nasiri, NM Bell, KI McLuckie, J Husby, C Abell, S Neidle and S Balasubramanian
Chem. Commun., 2014, 50, 1704-1707
DOI: 10.1039/C3CC48390H
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2013

241. Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain
FM Ferguson, O Fedorov, A Chaikuad, M Philpott, JR Muniz, I Felletar, F von Delft, T Heighton, S Knapp, C Abell and A Ciulli
J Med Chem, 2013, 56, 10183-10187
DOI: 10.1021/jm401582c
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240. A three-stage biophysical screening cascade for fragment-based drug discovery
EH Mashalidis, P Śledź, S Lang and C Abell
Nature Protocols, 2013, 8, 2309-2324
DOI: 10.1038/nprot.2013.130
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239. MicroRNA-Specific Argonaute 2 Protein Inhibitors
MF Schmidt, O Korb and C Abell
ACS Chem Biol, 2013, 8, 2122-2126
DOI: 10.1021/cb400246k
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238. Ultrarapid generation of femtoliter microfluidic droplets for single-molecule-counting immunoassays
J-u Shim, RT Ranasinghe, CA Smith, SM Ibrahim, F Hollfelder, WT Huck, D Klenerman and C Abell
ACS Nano, 2013, 7, 5955-5964
DOI: 10.1021/nn401661d
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237. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery
HL Silvestre, TL Blundell, C Abell and A Ciulli
Proc. Natl. Acad. Sci. U.S.A, 2013, 110, 12984-12989
DOI: 10.1073/pnas.1304045110
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236. Overcoming the limitations of fragment merging: rescuing a strained merged fragment series targeting Mycobacterium tuberculosis CYP121
SA Hudson, S Surade, AG Coyne, KJ McLean, D Leys, AW Munro and C Abell
ChemMedChem, 2013, 8, 1451-1456
DOI: 10.1002/cmdc.201300219
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235. Intra-species bacterial quorum sensing studied at single cell level in a double droplet trapping system
Y Bai, SN Patil, SD Bowden, S Poulter, J Pan, GP Salmond, M Welch, WT Huck and C Abell
Int. J. Mol. Sci, 2013, 14, 10570-10581
DOI: 10.3390/ijms140510570
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234. Nanoelectrospray ionization mass spectrometric study of Mycobacterium tuberculosis CYP121-ligand interactions
KM Duffell, SA Hudson, KJ McLean, AW Munro, C Abell and D Matak-Vinković
Anal Chem, 2013, 85, 5707-5714
DOI: 10.1021/ac400236z
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233. Sensitive, high throughput detection of proteins in individual, surfactant stabilized picoliter droplets using nanoESI mass spectrometry
C Smith, X Li, TH Mize, TD Sharpe, EI Graziani, C Abell and WTS Huck
Anal Chem, 2013, 85, 3812-3816
DOI: 10.1021/ac400453t
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232. Using a fragment-based approach to target protein-protein interactions
DE Scott, MT Ehebauer, T Pukala, M Marsh, TL Blundell, AR Venkitaraman, C Abell and M Hyvönen
ChemBioChem, 2013, 14, 332-342
DOI: 10.1002/cbic.201200521
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231. Discovery of Schaeffer's Acid analogues as lead structures of Mycobacterium tuberculosis type II dehydroquinase using a rational drug design approach
MF Schmidt, O Korb, S Lang, NI Howard, MVB Dias, TL Blundell and C Abell
ChemMedChem, 2013, 8, 54-58
DOI: 10.1002/cmdc.201200508
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2012

230. Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of Polo-like kinase 1
YS Tan, P Śledź, S Lang, CJ Stubbs, DR Spring, C Abell and RB Best
Angew. Chem. Int. Ed., 2012, 51, 10078-10081
DOI: 10.1002/anie.201205676
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229. Hierarchical virtual screening for the discovery of new molecular scaffolds in antibacterial hit identification
PJ Ballester, M Mangold, NI Howard, RL Robinson, C Abell, J Blumberger and JB Mitchell
J. R. Soc. Interface, (2012), 9, 3196-3207
DOI: 10.1098/rsif.2012.0569
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228. Application of fragment screening and merging to the discovery of inhibitors of the mycobacterium tuberculosis cytochrome P450 CYP121
SA Hudson, KJ McLean, S Surade, YQ Yang, D Leys, A Ciulli, AW Munro and C Abell
Angew. Chem. Int. Ed. 2012, 51 , 9311-9316
DOI: 10.1002/anie.201202544
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227. High-throughput interrogation of ligand binding mode using a fluorescence-based assay
P Śledź, S Lang, CJ Stubbs and C Abell
Angew. Chem. Int. Ed. 2012, 51 , 7680-7683
DOI: 10.1002/anie.201202660
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226. Fragment-based approaches in drug discovery and chemical biology
D Scott, A Coyne, S Hudson and C Abell
Biochemistry 2012, 51, 4990-5003
DOI: 10.1021/bi3005126
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225. Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening
GL Abrahams, A Kumar, S Savvi, AW Hung, S Wen, C Abell, CE Barry III, DR Sherman, HIM Boshoff and V Mizrahi
Chemistry and Biology 2013, 19, 844-54
DOI: 10.1016/j.chembiol.2012.05.020
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224. Mycobacterium tuberculosis cytochrome P450 enzymes: a cohort of novel TB drug targets
SA Hudson, KJ McLean, AW Munro and C Abell
Biochem. Soc. Trans. 2012, 40, 573-579
DOI: 10.1042/BST20120062
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223. Ligand-observed NMR in fragment-based approaches
P Śledź, C Abell and A Ciulli
in NMR of biomolecules: towards mechanistic systems biology Edited by I Bertini, KS McGreevy, G Parigi
Wiley-VCH Verlag GmbH & Co. KGaA 2012, 265-280
DOI: 10.1002/9783527644506.ch15
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222. Probing riboswitch-ligand interactions using thiamine pyrophosphate analogues
L Chen, E Cressina, N Dixon, K Erixon, K Agyei-Owusu, J Micklefield, AG Smith, C Abell and FJ Leeper
Org. Biomol.Chem 2012, 10, 5924-5931
DOI: 10.1039/C2OB07116A
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221. Structure of Escherichia coli aspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation
ME Webb, CMC Lobley, F Soliman, ML Kilkenny, AG Smith, TL Blundell and C Abell
Acta Cryst. Section F 2012, F68, 414-417
DOI: 10.1107/S1744309112009487
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220. Fabrication of microgel particles with complex shape via selective polymerization of aqueous two-phase systems
S Ma, J Thiele, X Liu, Y Bai, C Abell and WTS Huck
Small 2012, 1-5
DOI: 10.1002/smll.201102715
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219. One-step fabrication of supramolecular microcapsules from microfluidic droplets
J Zhang, RJ Coulston, ST Jones, J Geng, OA Scherman and C Abell
Science 2012, 335, 690-694
DOI: 10.1126/SCIENCE.1215416
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218. Single molecule fluorescence under conditions of fast flow
MH Horrocks, H Li, J-u Shim, RT Ranasinghe, RW Clarke, WTS Huck, C Abell and D Klenerman
Anal. Chem. 2012, 84, 179-185
DOI: 10.1021/AC202313D
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2011

217. Rv2607 from Mycobacterium tuberculosis is a pyridoxine 5'-phosphate oxidase with unusual substrate specificity
EH Mashalidis, T Mukherjee, P Śledź, D Matak-Vinković, H Boshoff, C Abell and CE Barry
PLoS One 2011, 6, e27643
DOI: 10.1371/JOURNAL.PONE.0027643
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216. Quantitative tracking of the growth of individual algal cells in microdroplet compartments
J Pan, AL Stephenson, E Kazamia, WTS Huck, JS Dennis, AG Smith and C Abell
Integr.Biol. 2011, 3, 1043-1051
DOI: 10.1039/C1IB00033K
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215. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis
MV Dias, WC Snee, KM Bromfield, RJ Payne, SK Palaninathan, A Ciulli, NI Howard, C Abell, JC Sacchettini and TL Blundell
Biochem 2011, 436, 729-739
DOI: 10.1042/BJ20110002
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214. Enzyme synthesis and activity assay in microfluidic droplets on a chip
N Wu, F Courtois, R Surjadi, J Oakeshott, TS Peat, CJ Easton, C Abell and YG Zhu
Eng. Life. Sci. 2011, 11, 157-164
DOI: 10.1002/elsc.201000043
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213. Identification of novel ligands for thiamine pyrophosphate (TPP) riboswitches
E Cressina, L Chen, M Moulin, FJ Leeper, C Abell and AG Smith
Biochem. Soc. Trans. 2011, 39, 652-657
DOI: 10.1042/BST0390652
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212. From crystal-packing to molecular recognition: prediction and discovery of a binding site on the surface of polo-like kinase 1
P Śledź, CJ Stubbs, S Lang, Y Yang, G J McKenzie, AR Venkitaraman, M Hyvönen and C Abell
Angew. Chemie Intl. Ed. 2011, 50, 4003-4006
DOI: 10.1002/anie.201008019
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211. A chelating dendritic ligand capped quantum dot: preparation, surface passivation, bioconjugation and specific DNA detection
D Zhou, Y Li, EA Hall, C Abell and D Klenerman
Nanoscale 2011, 3, 201-211
DOI: 10.1039/c0nr00462f
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210. Microdroplet fabrication of silver-agarose nanocomposite beads for SERS optiocal accumulation
S Abalde-Cela, B Auguié, M Fischlechner, WTS Huck, RA Alvarez-Puebla, LM Liz-Marzán and C Abell
Soft Matter 2011, 7, 1321-1325
DOI: 10.1039/c0sm00601g
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209. Controlling the contents of microdroplets by exploiting the permeability of PDMS
J-u Shim, SN Patil, JT Hodgkinson, SD Bowden, DR Spring, M Welch, WTS Huck, F Hollfelder and C Abell
Lab Chip 2011, 11, 1132-1137
DOI: 10.1039/C0LC00615G
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208. Monitoring a reaction at sub-millisecond resolution in picoliter volumes
A Huebner, C Abell, W Huck, C Baroud and F Hollfelder,
Anal. Chem. 2011, 83, 1462-1468.
DOI: 10.1021/ac103234a
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207. Fragment screening against the thiamine pyrophosphate riboswitch thiM
E Cressina, LH Chen, C Abell, FJ Leeper and AG Smith
Chem. Sci 2011, 2, 157-165
DOI: 10.1039/c0sc00406e
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2010

206. Isothermal DNA amplification using the T4 replisome: circular nicking endonuclease-dependent amplification and primase-based whole-genome amplification
Y Schaerli, V Stein, MM Spiering, SJ Benkovic, C Abell and F Hollfelder
Nucleic Acids Res 2010, 38, e201
DOI: 10.1093/nar/gkq795
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205. Fluorosurfactants for microdroplets: interfacial tension analysis
DJ Holt, RJ Payne, WY Chow and C Abell
J. Colloid Interface Sci 2010, 350, 205-211
DOI: 10.1016/j.jcis.2010.06.036
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204. Hydrophilic PDMS microchannels for high-throughput formation of oil-in-water microdroplets and water-in-oil-in-water double emulsions
W-AC Bauer, M Fischlechner, C Abell and WTS Huck
Lab Chip 2010, 10, 1814-1819
DOI: 10.1039/c004046k
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203. Management of the diffusion of 4-methylumbelliferone across phases in microdroplet-based systems for in vitro protein evolution
N Wu, F Courtois, YG Zhu, J Oakeshott, C Easton and C Abell
Electrophoresis 2010, 31, 3121-3128
DOI: 10.1002/elps.201000140
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202. Inhibition of chorismate-utilising enzymes by 2-amino-4-carboxypyridine and 4-carboxypyridone and 5-carboxypyridone analogues
RJ Payne, EM Bulloch, O Kerbarh and C Abell
Org. Biomol. Chem 2010, 8, 3534-3542
DOI: 10.1039/c004062b
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201. Optimisation of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase
P Sledź, HL Silvestre, AW Hung, A Ciulli, TL Blundell and C Abell
J. Am. Chem. Soc. 2010, 132, 4544-4545
DOI: 10.1021/ja100595u
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200. A fragment-based approach to identifying ligands for riboswitches
L Chen, E Cressina, FJ Leeper, AG Smith and C Abell
A.C.S. Chem. Biol. 2010, 5, 355-358
DOI: 10.1021/cb9003139
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199. Drugging challenging targets using fragment-based approaches
AG Coyne, DE Scott and C Abell
Curr. Opin. Chem. Biol. 2010, 14, 299-307
DOI: 10.1016/j.cbpa.2010.02.010
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198. Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology
AB Theberge, F Courtois, Y Schaerli, M Fischlechner, C Abell, F Hollfelder and WTS Huck
Angew. Chemie Int. Ed. 2010, 49, 5846-5868
DOI: 10.1002/anie.200906653
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197. A double droplet trap system for studying mass transport across a droplet-droplet interface
Y Bai, X He, D Liu, SN Patil, D Bratton, A Huebner, F Hollfelder, C Abell and WTS Huck
Lab Chip 2010, 10, 1281-1285
DOI: 10.1039/b925133b
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196. Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activities of chorismate-utilizing enzymes
S Sridharan, N Howard, O Kerbarh, M Blaszczyk, C Abell and TL Blundell
J. Mol. Biol. 2010, 397, 290-300
DOI: 10.1016/j.jmb.2010.01.019
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195. Tri-partite complex for axonal transport drug delivery achieves pharmacological effect
AG Filler, GT Whiteside, M Bacon, M Frederickson, FA Howe, MD Rabinowitz, AJ Sokoloff, TW Deacon, C Abell, R Munglani, JR Griffiths, BA Bell and AML Lever
B.M.C. Neuroscience 2010, 11, 8
DOI: 10.1186/1471-2202-11-8
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194. Synthesis of novel fluorous surfactants for microdroplet stabilisation in fluorous oil streams
DJ Holt, RJ Payne and C Abell
J. Fluorine Chemistry 2010, 131, 398-407
DOI: 10.1016/j.jfluchem.2009.12.010
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193. Vancomycin dimer formation between analogues of bacterial peptidoglycan surfaces probed by force spectroscopy
M Batchelor, D Zhou, MA Cooper, C Abell and T Rayment
Org. Biomol. Chem. 2010, 8, 1142-1148
DOI: 10.1039/b919347b
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2009

192. Simultaneous determination of gene expression and enzymatic activity in individual bacterial cells in microdroplet compartments
J-u Shim, LF Olguin, G Whyte, D Scott, A Babtie, C Abell, WTS Huck and F Hollfelder
J. Am. Chem. Soc. 2009, 131, 15251-15256
DOI: 10.1021/ja904823z
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191. Biofunctionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platforms
J Trmcic-Cvitas, E Hasan, M Ramstedt, X Li, MA Cooper, C Abell, WTS Huck and J Gautrot
Biomacromolecules 2009, 10, 2885-2894
DOI: 10.1021/bm900706r
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190. A fragment-based approach to probing adenosine recognition sites using dynamic combinatorial chemistry
DE Scott, GJ Dawes, C Abell and A Ciulli
ChemBioChem 2009 10, 17, 2772 - 2779
DOI: 10.1002/cbic.200900537
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189. Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase
AW Hung, HL Silvestre, S Wen, A Ciulli, TL Blundell and C Abell
Angew. Chemie Intl. Ed. 2009, 48, 8452-8456
DOI: 10.1002/anie.200903821
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188. Fragment-based drug discovery in academia: experiences from a tuberculosis programme
T J Heikkila, S Surade, HL Silvestre, MVB Dias, A Ciulli, KM Bromfield, DE Scott, NI Howard, S Wen, AH Wei, DM Osborne, C Abell and TL Blundell
In Proceedings of the NATO International School of Crystallography, 40th Course 'From Molecules to Medicine: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism'. J. L. Sussman and P. Spadon, Ed., Springer, 2009, 21-36
ISBN: 978-90-481-2337-7
187. Controlling the retention of small molecules in emulsion microdroplets for use in cell-based assays
F Courtois, LF Olguin, G Whyte, A Theberge, WTS Huck, F Hollfelder and C Abell
Anal. Chem. 2009, 81, 3008-3016
DOI: 10.1021/ac802658n
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186. Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of chorismate utilising enzymes
RJ Payne, EMM Bulloch, MM Toscano, O Kerbarh and C Abell
Org. Biomol. Chem. 2009, 7, 2421-2429
DOI: 10.1039/b901694e
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185. An integrated cell culture lab on a chip: modular microdevices for cultivation of mammalian cells and delivery into microfluidic microdroplets
H Hufnagel, A Huebner, C Gülch, K Güse, C Abell and F Hollfelder
Lab Chip 2009, 9, 1576-1582
DOI: 10.1039/b821695a
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184. Simultaneous measurement of reactions in microdroplets filled by concentration gradients
N Damean, LF Olguin, F Hollfelder, C Abell and WTS Huck
Lab Chip 2009, 9, 1707-1713
DOI: 10.1039/b821021g
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183. Coupling microdroplet microreactors with mass spectrometry: reading the contents of single droplets on line
LM Fidalgo, G Whyte, BT Ruotolo, JLP Benesch, F Stengel, C Abell, CV Robinson and WTS Huck
Angew. Chimie Intl. Ed. 2009, 48, 3665-3668
DOI: 10.1002/anie.200806103
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182. Continuous-flow polymerase chain reaction of single-copy DNA in microfluidic microdroplets
Y Schaerli, RC Wootton, T Robinson, V Stein, C Dunsby, MAA Neil, PMW French, AJ deMello, C Abell and F Hollfelder
Anal. Chem. 2009, 81, 302-306
DOI: 10.1021/ac802038c
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181. Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays
A Huebner, D Bratton, G Whyte, M Yang, AJ deMello, C Abell and F Hollfelder
Lab Chip 2009, 9, 692-698
DOI: 10.1039/b813709a
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2008

180. Towards engineering increased pantothenate (Vitamin B5) levels in plants
E Chakauya, KM Coxon, M Wei, M V MacDonald, T Barsby, C Abell and AG Smith
Plant Mol. Biol. 2008, 68, 1-46
DOI: 10.1007/s11103-008-9386-5
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179. Nanomechanical detection of antibiotic–mucopeptide binding in a model for superbug drug resistance
JW Ndieyira, M Watari, AD Barrera, M Batchelor, D Zhou, MA Cooper, T Strunz, B Dueck, C Abell, MA Horton, T Rayment, G Aeppli and RA McKendry
Nature Nanotechnology 2008, 3, 691-696
DOI: 10.1038/nnano.2008.275
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178. Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate
A Ciulli, DE Scott, M Ando, F Reyes, SA Saldanha, KL Tuck, DY Chirgadze, TL Blundell and C Abell
ChemBioChem 2008, 9, 2606-2611
DOI: 10.1002/cbic.200800437
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177. Development of quantitative cell-based enzyme assays in microdroplets
A Huebner, LF Olguin, D Bratton, G Whyte, WTS Huck, AJ de Mello, JB Edel, C Abell and F Hollfelder
Anal. Chem. 2008, 80, 3890-3896
DOI: 10.1021/ac800338z
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176. From microdroplets to microfluidics: selective emulsion separation in microfluidic devices
LM Fidalgo, G Whyte, D Bratton, C Abell and WTS Huck
Angew. Chimie Intl. Ed. 2008, 47, 2042-2045
DOI: 10.1002/anie.200704903
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175. A compact functional quantum dot-DNA conjugate: preparation, hybridization and specific label-free DNA detection
D Zhou, L Ying, X Hong, EA Hall, C Abell and D Klenerman
Langmuir 2008, 24, 1659-1664
DOI: 10.1021/la703583u
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174. An integrated device for monitoring time-dependent in vitro expression from single genes in picolitre droplets
F Courtois, LF Olguin, G Whyte, D Bratton, WTS Huck, C Abell and F Hollfelder
ChemBioChem 2008, 9, 439-446
DOI: 10.1002/cbic.200700536
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173. Discovery and extrapolation of fragment structures towards drug design
A Ciulli, TL Blundell and C Abell
In 'Computational and structural approaches to drug discovery" Ed R M Stroud, J Finer-Moore, 2008, Royal Society of Chemistry, pp 293-318
ISBN:978-0-85404-365-1
172. Single step biocompatible coating for sulfhydryl coupling of receptors using 2-(pyridinyldithio)ethyl-carbamoyl dextran
X Li, C Abell and MA Cooper
Colloids and Surfaces B: Biointerfaces 2008, 61, 113-117
DOI: 10.1016/j.colsurfb.2007.06.026
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2007

171. Fragment-based approaches to enzyme inhibition
A Ciulli and C Abell
Curr. Op. Biotech. 2007, 18, 489-496
DOI: 10.1016/j.copbio.2007.09.003
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170. Investigating specific interactions between carbonic anhydrase and a sulfonamide inhibitor by single molecule force spectroscopy
SG Kamper, L Porter-Peden, R Blankespoor, K Sinniah, D Zhou, C Abell and T Rayment
Langmuir 2007 23, 12561-12565
DOI: 10.1021/la702148v
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169. Coenzyme biosynthesis: enzyme mechanism, structure and inhibition
DE Scott, A Ciulli and C Abell
Nat. Prod. Reports 2007, 24, 1009-1026
DOI: 10.1039/b703108b
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168. Surface-induced droplet fusion in microfluidic devices
LM Fidalgo, C Abell and WTS Huck
Lab Chip 2007, 7, 984-986
DOI: 10.1039/b708091c
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167. Design, synthesis and structural studies on potent biaryl inhibitors of type II dehydroquinases
RJ Payne, A Riboldi-Tunnicliffe, O Kerbarh, AD Abell, AJ Lapthorn and C Abell
ChemMedChem 2007, 2, 1010-1013
DOI:10.1002/cmdc.200700062
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166. Rational design, synthesis and evaluation of nanomolar type II dehydroquinase inhibitors
RJ Payne, F Peyrot, O Kerbarh, AD Abell and C Abell
ChemMedChem 2007, 2, 1015-1029
DOI: 10.1002/cmdc.200700032
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165. Nucleophile selectivity of chorismate-utilizing enzymes
O Kerbarh, A Ciulli, DY Chirgadze, TL Blundell and C Abell
ChemBioChem 2007, 8, 622-624
DOI: 10.1002/cbic.200700019
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164. Quantitative detection of protein expression in single cells using droplet microfluidics
A Huebner, M Srisa-Art, D Holt, C Abell, F Hollfelder, AJ deMello and JB Edel
Chem. Commun. 2007, 1218-1220
DOI: 10.1039/b618570c
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163. Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change and cooperativity
A Ciulli, DY Chirgadze, AG Smith, TL Blundell and C Abell
J. Biol. Chem. 2007, 282, 8487-8497
DOI: 10.1074/jbc.M611171200
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162. Nanomolar inhibition of type II dehydroquinase based on the enolate reaction mechanism
MD Toscano, RJ Payne, A Chiba, O Kerbarh and C Abell
ChemMedChem 2007, 2, 101-112
DOI: 10.1002/cmdc.200600194
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161. pH tuneable binding of 2'-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study
A Ciulli, CMC Lobley, KL Tuck, AG Smith, TL Blundell and C Abell
Acta Cryst. 2007, D63, 171-178
DOI: 10.1107/S0907444906044465
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2006

160. The design and synthesis of inhibitors of pantothenate synthetase
KL Tuck, SA Saldanha, LM Birch, AG Smith and C Abell
Org. Biomol. Chem. 2006, 4, 3598-3610
DOI: 10.1039/b609482a
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159. Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods
A Ciulli, G Williams, AG Smith, TL Blundell and C Abell
J. Med. Chem. 2006, 49, 4992-5000
DOI: 10.1021/jm060490r
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158. Building three-dimensional nanostructures with active enzymes by surface templated layer-by-layer assembly
S Rauf, D Zhou, C Abell, D Klenerman and D-J Kang
Chem. Commun. 2006, 1721-1723
DOI: 10.1039/b517557g
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157. Macroscopic, 2D networks self-assembled from nanometre-sized protein/DNA complexes
M Manzanera, D J Frankel, H Li, D Zhou, A Bruckbauer, P Kreutzmann, JM Blackburn, C Abell, T Rayment, D Klenerman and PD Barker
Nano Lett. 2006, 6, 365-370
DOI: 10.1021/nl051599+
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156. Pantothenate biosynthesis in higher plants: advances and challenges
E Chakauya, KM Coxon, HM Whitney, JL Ashurst, C Abell and AG Smith
Physiologia Plantarum 2006, 126, 319-329
DOI: 10.1111/j.1399-3054.2006.00683.x
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155. Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors
N Howard, C Abell, W Blakemore, R Carr, G Chessari, M Congreve, S Howard, H Jhoti, CW Murray, LCA Seavers and RLM van Montfort
J. Med. Chem. 2006, 49, 1346-1355
DOI: 10.1021/jm050850v
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154. A reversible pH-Driven DNA nanoswitch array
D Liu, A Bruckbauer, C Abell, S Balasubramanian, D-J Kang, D Klenerman and D Zhou
J. Am. Chem. Soc. 2006, 128, 2067-2071
DOI: 10.1021/ja0568300
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153. Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate
O Kerbarh, DY Chirgadze, TL Blundell and C Abell
J. Mol. Biol. 2006, 357, 524-534
DOI: 10.1016/j.jmb.2005.12.078
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152. Electrostatic orientation of enzymes on surfaces for ligand screening probed by force spectroscopy
X Wang, D Zhou, K Sinniah, C Clarke, L Birch, H Li, T Rayment and C Abell
Langmuir 2006, 22, 887-892
DOI: 10.1021/la0525731
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2005

151. Design and synthesis of aromatic inhibitors of anthranilate synthase - part II
RJ Payne, EMM Bulloch, AD Abell and C Abell
Org. Biomol. Chem. 2005, 3, 3629-3635
DOI: 10.1039/b510633h
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150. Rational design of new bifunctional inhibitors of type II dehydroquinase
MD Toscano, KA Stewart, JR Coggins, AJ Lapthorn and C Abell
Org. Biomol. Chem. 2005, 3, 3102-3104
DOI: 10.1039/b507156a
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149. Fluorescence resonance energy transfer between a quantum dot donor and a dye acceptor attached to DNA
D Zhou, JD Piper, C Abell, D Klenerman, DJ Kang and LM Ying
Chem. Commun. 2005, 4807-4809
DOI: 10.1039/b508911e
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148. Biophysical tools to monitor enzyme-ligand interactions of enzymes involved in vitamin biosynthesis
A Ciulli and C Abell
Biochem. Soc. Trans. 2005, 33, 767-771
DOI: 10.1042/BST0330767
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147. Mechanistic and inhibition studies of chorismate-utilizing enzymes
O Kerbarh, EMM Bulloch, RJ Payne, T Sahr, F Rabeille and C Abell
Biochem. Soc. Trans. 2005, 33, 763-766
DOI: 10.1042/BST0330763
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146. Pantothenate biosynthesis in higher plants
KM Coxon, E Chauauya, HH Ottenhof, HM Whitney, TL Blundell, C Abell and AG Smith
Biochem. Soc. Trans. 2005, 33, 743-746
DOI: 10.1042/BST0330743
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145. Salicylate biosynthesis: over-expression, purification and characterization of Irp9, a bifunctional salicylate synthase from Yersinia enterocolitica
O Kerbarh A Ciulli, NI Howard and C Abell
J. Bact. 2005, 187, 5061-5066
DOI: 10.1128/JB.187.15.5061-5066.2005
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144. The crystal structure of Escherichia coli ketopantoate reductase in complex with NADP+ bound
CMC Lobley, A Ciulli, H Whitney, G Williams, AG Smith, C Abell and TL Blundell
Biochemistry 2005, 44, 8930-8939
DOI: 10.1021/bi0502036
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143. Design and synthesis of aromatic inhibitors of anthranilate synthase
RJ Payne, M Toscano, EM Bulloch, AD Abell and C Abell
Org. Biomol. Chem. 2005, 3, 2271-2281
DOI: 10.1039/b503802b
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142. Inhibition studies on salicylate synthase
RJ Payne, O Kerbarh, RN Miguel, AD Abell and C Abell
Org. Biomol. Chem. 2005, 3, 1825-1827
DOI: 10.1039/b503800f
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141. Fabrication of 3D surface structures with highly fluorescent quantum dots by surface-templated layer-by-layer assembly
D Zhou, A Bruckbauer, C Abell, D Klenerman and D-J Kang
Advanced Materials 2005, 17, 1243-1248
DOI: 10.1002/adma.200401520
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140. Detection of covalent intermediates formed in the reaction of 4 amino 4 deoxychorismate synthase
EMM Bulloch and C Abell
ChemBioChem 2005, 6, 832-834
DOI: 10.1002/cbic.200400385
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2004

139. Biosynthesis of pantothenate
ME Webb, AG Smith and C Abell
Nat. Prod. Rep. 2004, 21, 695-721
DOI: 10.1039/b316419p
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138. A simple voltage controlled enzymatic nanoreactor produced in the tip of a nanopipet
A Bruckbauer, D Zhou, L Ying, C Abell and D Klenerman
Nano. Lett. 2004, 4, 1859-1862
DOI: 10.1021/nl049029h
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137. Influence of the foundation layer on the layer-by-layer assembly of poly-L-lysine and poly(styrenesulfonate) and its usage in the fabrication of 3D microscale features
D Zhou, A Bruckbauer, M Batchelor, D-J Kang, C Abell and D Klenerman
Langmuir 2004, 20, 9089-9094
DOI: 10.1021/la048619s
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136. Identification of 4-amino-4-deoxychorismate synthase as the molecular target for the antimicrobial action of (6S)-6-fluoroshikimate
EMM Bulloch, MA Jones, EJ Parker, AP Osborne, E Stimson, GM Davies, JR Coggins and C Abell
J. Am. Chem. Soc. 2004, 126, 9912-9913
DOI: 10.1021/ja048312f
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135. (1R,4S,5R)-3-Fluoro-1,4,5-trihydroxy-2-cyclohexene-1-carboxylic acid: the fluoro analogue of the enolate intermediate in the reaction catalysed by type II dehydroquinases
M Frederickson, AW Roszak, JR Coggins, AJ Lapthorn and C Abell
Org. Biomol. Chem. 2004, 2, 1592-1596
DOI: 10.1039/b404535a
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134. An addressable antibody nanoarray produced on a nanostructured surface
A Bruckbauer, D Zhou, D-J Kang, YE Korchev, C Abell and D Klenerman
J. Am. Chem. Soc. 2004, 126, 6508-6509
DOI: 10.1021/ja0317426
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133. A novel phase-switching protecting group for multi-step parallel solution phase synthesis
X Li, C Abell, M S Congreve, B Warrington and M Ladlow
Org. Biomol. Chem. 2004, 2, 989-998
DOI: 10.1039/b400110a
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132. Method to determine the spring constant of atomic force microscope cantilevers
CT Gibson, DJ Johnson, C Anderson, C Abell and T Rayment
Rev. Sci. Instrum. 2004, 75, 565-567
DOI: 10.1063/1.1642750
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131. Organisation of the pantothenate (vitamin B5) biosynthesis pathway in higher plants
HH Ottenhof, JL Ashurst, HM Whitney, SA Saldanha, F Schmitzberger, HS Gweon, TL Blundell, C Abell and AG Smith
Plant J. 2004, 37, 61-72
DOI: 10.1046/j.1365-313X.2003.01940.x
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2003

130. Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia)
X Li, C Abell, B Warrington and M Ladlow
Org. Biomol. Chem. 2003, 1, 4392-4395
DOI: 10.1039/b307549d
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129. Structural constraints on protein self-processing in L-aspartate-α-decarboxylase
F Schmitzberger, ML Kilkenny, CMC Lobley, ME Webb, M Vinković, D Matak-Vinković, M Witty, DY Chirgadze, AG Smith, C Abell and TL Blundell
EMBO J. 2003, 22, 6193-6204
DOI: 10.1093/emboj/cdg575
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128. AFM study on protein immobilization on charged surfaces at the nanoscale: towards the fabrication of three-dimensional protein nanostructures
D Zhou, X Wang, L Birch, T Rayment and C Abell
Langmuir 2003, 19, 10557-10562
DOI: 10.1021/la035491q
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127. Parallel solid-phase synthesis and evaluation of inhibitors of Streptomyces coelicolor type II dehydroquinase
C González-Bello, E Lence, MD Toscano, L Castedo, JR Coggins and C Abell
J. Med. Chem. 2003, 46, 5735-5744
DOI: 10.1021/jm030987q
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126. Building three-dimensional surface biological assemblies on the nanometer scale
D Zhou, A Bruckbauer, L Ying, C Abell and D Klenerman
Nano. Lett. 2003, 3, 1517-1520
DOI: 10.1021/nl0345926
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125. Enzymic synthesis of 3-[3-13C]dehydroquinic acid
M Frederickson, EJ Parker, JR Coggins and C Abell
Org. Biomol. Chem. 2003, 1, 3271-3273
DOI: 10.1039/b309666a
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124. Novel selenium containing non-detergent sulphobetaines
M Frederickson, L Vuillard and C Abell
Tetrahedron Lett. 2003, 44, 7925-7928
DOI: 10.1016/j.tetlet.2003.09.004
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123. Rapid screening by MALDI-TOF mass spectrometry to probe binding specificity at enzyme active sites
ME Webb, E Stephens, AG Smith and C Abell
Chem. Commun. 2003, 2416-2417
DOI: 10.1039/b308182f
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122. Label-free detection of DNA hybridisation at the nanoscale: a highly sensitive and selective approach using atomic-force microscopy
D Zhou, K Sinniah, C Abell and T Rayment
Angewandte Chemie 2003, 42, 4934-4937
DOI: 10.1002/anie.200352178
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121. Multicomponent submicron features of biomolecules created by voltage controlled deposition from a nanopipet
A Bruckbauer, D Zhou, L Ying, Y E Korchev, C Abell and D Klenerman
J. Am. Chem. Soc. 2003, 125, 9834-9839
DOI: 10.1021/ja035755v
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120. Design, synthesis and evaluation of bifunctional inhibitors of type II dehydroquinase
MD Toscano, M Frederickson, DP Evans, JR Coggins, C Abell and C González-Bello
Org. Biol. Chem. 2003, 1, 2075-2083
DOI: 10.1039/b301731a
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119. Comparative analysis of the Escherichia coli ketopantoate hydroxymethyltransferase crystal structure confirms it as a member of the (βα)8 phosphoenolpyruvate/pyruvate superfamily
F Schmitzberger, AG Smith, C Abell and TL Blundell
J. Bacteriol. 2003, 185, 4163-4171
DOI: 10.1128/JB.185.14.4163-4171.2003
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118. Structural insights into the evolution of the pantothenate-biosynthesis pathway
CMC Lobley, F Schmitzberger, ML Kilkenny, H Whitney, HH Ottenhof, E Chakauya, ME Webb, LM Birch, KL Tuck, C Abell, AG Smith and TL Blundell
Biochem. Soc. Trans. 2003, 31, 563-571
DOI: 10.1042/bst0310563
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117. Experiences with the shikimate-pathway enzymes as targets for rational drug design
JR Coggins, C Abell, L B Evans, M Frederickson, DA Robinson, AW Roszak and AJ Lapthorn
Biochem. Soc. Trans. 2003, 31, 548-552
DOI: 10.1042/bst0310548
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116. Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites
F von Delft, T Inoue, SA Saldanha, H H Ottenhof, F Schmitzberger, LM Birch, V Dhanaraj, M Witty, AG Smith, TL Blundell and C Abell
Structure 2003, 11, 985-996
DOI: 10.1016/S0969-2126(03)00158-8
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115. A novel anthracenyl tagged protecting group for "phase-switching" applications in parallel synthesis
X Li, C Abell and M Ladlow
J. Org. Chem. 2003, 68, 4189-4194
DOI: 10.1021/jo034219i
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114. A convenient method for the synthesis of dehydroquinic acid
C Le Sann, C Abell and AD Abell
Synth. Comm. 2003, 33, 527-533
DOI: 10.1081/SCC-120015805
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113. Chiral discrimination of basic and hydrophobic molecules by chemical force microscopy
M Mahapatro, C Gibson, C Abell and T Rayment
Ultramicroscopy 2003, 97, 297-301
DOI: 10.1016/S0304-3991(03)00055-X
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112. Calibration of AFM cantilever spring constants
CT Gibson, BL Weeks, C Abell, T Rayent and S Myhra
Ultramicroscopy 2003, 97, 113-118
DOI: 10.1016/S0304-3991(03)00035-4
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111. Systematic manipulation of surface chemical reaction on the nanoscale: a novel approach for constructing three-dimensional nanostructures
X Wang, D Zhou, T Rayment and C Abell
Chem. Commun. 2003, 474-476
DOI: 10.1039/b211906d
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2002

110. A sensitive and economical method to directly detect particles.
MA Cooper, VP Ostanin, D Klenerman, A Slepstov, R Karamanska, FN Dultsev, K Stirrups, S Kelling, T Minson and C Abell
Proceedings of IEEE Sensors 2002, 1,1042-1045
109. High-throughput x-ray crystallography for drug discovery.
TL Blundell, C Abell, A Cleasby, MJ Hartshorn, IJ Tickle, E Parasini and H Jhoti
In "Drug design, cutting edge approaches" Ed. D Flower
Royal Soc. Chem. 2002, 53-59
ISBN: 0-85404-816-2
108. The use of FTICR-MS to detect chemical tags from a combinatorial library
MH Todd and C Abell
Analyst 2002, 127, 1399-1406
DOI: 10.1039/b203957p
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107. Use of atomic force microscopy for making addresses in DNA coatings
D Zhou, K Sinniah, C Abell and T Rayment
Langmuir 2002, 18, 8278-8281
DOI: 10.1021/la0258547
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106. A simple method for the preparation of 3-hydroxyiminodehydroquinate, a potent inhibitor of type II dehydroquinase
C Le Sann, C Abell and AD Abell
Perkin Trans I 2002, 2065-2068
DOI: 10.1039/b206066c
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105. Vinyl fluoride as an isoelectronic replacement for an enolate anion: inhibition of type II dehdyroquinases
M Frederickson, JR Coggins and C Abell
Chem. Commun. 2002, 1886-1887
DOI: 10.1039/b205105m
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104. Writing with DNA and protein using a nanopipet for controlled delivery
A Bruckbauer, L Ying, A M Rothery, D Zhou, A I Shevchuk, C Abell, Y E Korchev and D Klenerman
J. Am. Chem. Soc. 2002, 124, 8810-8811
DOI: 10.1021/ja026816c
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103. Creating nanoscale patterns of dendrimers on silicon surfaces with dip-pen nanolithography
R McKendry, WTS Huck, B Weeks, M Fiorini, C Abell and T Rayment
Nano Letts. 2002, 2, 713-716
DOI: 10.1021/nl020247p
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102. The structure and mechanism of type II dehydroquinase from Streptomyces coelicolor
AW Roszak, DA Robinson, T Krell, IS Hunter, M Frederickson, C Abell, JR Coggins and AJ Lapthorn
Structure 2002, 10, 493-503
DOI: 10.1016/S0969-2126(02)00747-5
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101. High throughput crystallography for lead discovery in drug design
TL Blundell, H Jhoti and C Abell
Nature Rev., Drug Discovery 2002, 1, 45-54
DOI: 10.1038/nrd706
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2001

100. Substrate deactivation of phenylalanine-sensitive 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase by erythrose 4-phosphate
EJ Parker, EMM Bulloch, GB Jameson and C Abell
Biochemistry 2001, 40, 14821-14828
DOI: 10.1021/bi010928j
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99. Crystal structure of Escherichia coli ketopantoate reductase at 1.7 Ĺ resolution and insight into the enzyme mechanism
D Matak-Vinković, M Vinković, SA Saldanha, JL Ashurst, F von Delft, T Inoue, R Nunez Miguel, AG Smith, TL Blundell and C Abell
Biochemistry 2001, 40, 14493-14500
DOI: 10.1021/bi011020w
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98. Identification of Tyr58 as the proton donor in the aspartate-α-decarboxylase reaction
SA Saldanha, LM Birch, ME Webb, BK Nabbs, F von Delft, AG Smith and C Abell
Chem. Commun. 2001, 18, 1760-1761
DOI: 10.1039/b106090m
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97. Direct and sensitive detection of a human virus by rupture event scanning
MA Cooper, FN Dultsev, T Minson, VP Ostanin, C Abell and D Klenerman
Nature Biotech 2001, 19, 833-837
DOI: 10.1038/nbt0901-833
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96. Direct and quantitative detection of bacteriophage by "hearing" surface detachment using a quartz crystal microbalance
FN Dultsev, RE Speight, MT Fiorini, JE Blackburn, C Abell, VP Ostanin and D Klenerman
Anal. Chem. 2001, 73, 3953-3939
DOI: 10.1021/ac0100897
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95. Novel chemical tagging method for combinatorial synthesis utilizing Suzuki chemistry and fourier transform ion cyclotron resonance mass spectrometry
MH Todd and C Abell
J. Combi. Chem. 2001, 3, 319-327
DOI: 10.1021/cc000112m
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94. The crystal structure of E. coli pantothenate synthetase confirms it as a new member of the cytidylytransferase superfamily
F von Delft, A Lewendon, V Dhanaraj, TL Blundell, C Abell and AG Smith
Structure 2001, 9, 439-450
DOI: 10.1016/S0969-2126(01)00604-9
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93. Preparation of symmetrical and unsymmetrical protein-DNA conjugates using DNA as a molecular scaffold
JM Tomkins, BK Nabbs, K Barnes, M Legido, J Blacker, RA McKendry and C Abell
ChemBioChem 2001, 5, 375-378
DOI: 10.1002/1439-7633(20010504)2:5<375::AID-CBIC375>3.0.CO;2-I
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92. Chemical force microscopy with active enzymes
M Fiorini, R McKendry, MA Cooper, T Rayment and C Abell
Biophys. J. 2001, 80, 2471-2476
DOI: 10.1016/S0006-3495(01)76215-7
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91. A nondestructive technique for determining the spring constant of atomic force microscope cantilevers
CT Gibson, BL Weeks, JRI Lee, C Abell and T Rayment
Rev. Sci. Instrum. 2001, 72, 2340-2343
DOI: 10.1063/1.1361080
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2000

90. Studies with substrate and cofactor analogues provide evidence for a radical mechanism in the chorismate synthease reaction
A Osborne, RNF Thorneley, C Abell and S Bornemann
J. Biol. Chem. 2000, 275, 35825-35830
DOI: 10.1074/jbc.M005796200
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89. The attachment and cleavage of phenols from solid supports and their single bead mass spectral analysis
MH Todd and C Abell
Tetrahedron Lett. 2000, 8183-8187
DOI: 10.1016/S0040-4039(00)01431-3
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88. Binding of vancomycin group antibiotics to D-alanine and D-Lactate presenting self-assembled monolayers
MA Cooper, MT Fiorini, C Abell and DH Williams
Biorg. Med. Chem. 2000, 8, 2609-2616
DOI: 10.1016/S0968-0896(00)00184-X
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87. A secondary β deuterium kinetic isotope effect in the chorismate synthase reaction
S Bornemann, M-E Theoclitou, M Brune, MR Webb, RNF Thorneley and C Abell
Bioorg. Chem. 2000, 28, 191-204
DOI: 10.1006/bioo.2000.1174
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86. Reductive cleavage of N-O bonds using samarium (II) iodide in a traceless release strategy for solid phase synthesis
RM Myers, SP Langston, SP Conway and C Abell
Org. Lett. 2000, 2, 1349-1352
DOI: 10.1021/ol0055162
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85. Irreversible inhibition of type I dehydroquinase by substrates for type II dehydroquinase
C González-Bello, JM Harris, MK Manthey, JR Coggins and C Abell
BioMed. Chem. Letts. 2000, 10, 407-409
DOI: 10.1016/S0960-894X(00)00057-3
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84. Mechanistic studies on type I and type II dehydroquinases with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids
EJ Parker, C González-Bello, JR Coggins, AR Hawkins and C Abell
Bioorg. Med. Chem. Letts. 2000, 10, 231-234
DOI: 10.1016/S0960-894X(99)00660-5
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83. Palladium-catalysed carbon-carbon bond formation on solid supports.
MH Todd and C Abell
In "Solid-Phase Organic Synthesis" Ed. K. Burgess, Wiley, 2000, pp.25-79
ISBN 978-0-47131-825-5
DOI: 10.1002/0471228249.ch2
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Pre 2000

82. A novel safety-catch linker for the solid-phase synthesis of amides and esters
MH Todd, SF Oliver and C Abell
Org. Lett. 1999, 1, 1149-1151
DOI: 10.1021/ol990785h
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81. Use of quinic acid as template in solid-phase combinatorial synthesis
CW Phoon and C Abell
J. Combinatorial Chem. 1999, 1, 485-492
DOI: 10.1021/cc990027i
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80. How much chemistry is there in chemical force microscopy?
R McKendry, M-E Theoclitou, C Abell and T Rayment
Jap. J. Appl. Phys. 1999, 38, 3901-3907
DOI: 10.1143/JJAP.38.3901
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79. The final step of pantothenate biosynthesis in higher plants: cloning and characterisation of pantothenate synthetase from Lotus japonicus and Oryza sativum (Rice)
U Genschel, CA Powell, C Abell and AG Smith
Biochem. J. 1999, 341, 669-678
DOI: 10.1042/bj3410669
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78. Combinatorial synthetic design
SF Oliver and C Abell
Curr. Op. Chem. Biol. 1999, 3, 299-306
DOI: 10.1016/S1367-5931(99)80046-5
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77. Adventures with atomic force microscopy
C Abell, R McKendry and T Rayment
In "Bioorganic Chemistry: Highlights and New Aspects" Ed. U Diederichsen, TK Lindhorst, B Westermann and L Wessjohann, Wiley-VCH, 1999, pp 358-364
ISBN: 3527296654
76. Selective inhibition of type II dehydroquinases
M Frederickson, EJ Parker, AR Hawkins, JR Coggins and C Abell
J. Org. Chem. 1999, 64, 2612-2613
DOI: 10.1021/jo990004q
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75. Synthesis of 4-deoxyquinic, 4-deoxyshikimate and 4-deoxy-3-dehydroshikimic acids
C González-Bello, AR Hawkins, JR Coggins and C Abell
J. Chem. Soc., Perkin Trans. I 1999, 849-854
DOI: 10.1039/A809809C
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74. Enzymology and molecular biology of the shikimate pathway
C Abell
In "Comprehensive Natural Products Chemistry - Vol. 1", ed. U Sankawa, 1999, Elsevier, Amsterdam, pp 573-607
ISBN: 0080431534 (v.1)
73. A decarboxylative traceless linker approach for the solid phase synthesis of quinazolines
JM Cobb, MT Fiorini, CR Goddard, M-E Theoclitou and C Abell
Tetrahedron Lett. 1999, 1045-1048
DOI: 10.1016/S0040-4039(99)80108-7
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72. The use of trichloroacetimidate-activated resin for ester formation
CW Phoon, S Oliver and C Abell
Tetrahedron Lett. 1998, 7959-7962
DOI: 10.1016/S0040-4039(98)01729-8
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71. Enzymes that exploit imines - one way or the other
C Abell
Biochem. Soc. Trans. 1998, 26, 310-315
DOI: 10.1042/bst0260310
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70. Comparative study of the protection of modified and unmodified dsDNA by cationic and non-cationic lipids and liposomes to digestion by DNase I
M Legido and C Abell
J. Chem. Soc., Perkin Trans. 2 1998, 1283-1285
DOI: 10.1039/A802212G
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69. Crystal structure of aspartate decarboxylase at 2.2 Ĺ resolution provides evidence for an ester in protein self-processing
A Albert, V Dhanaraj, U Genschel, G Khan, MK Ramjee, R Pulido, BL Sibanda, F von Delft, M Witty, TL Blundell, AG Smith and C Abell
Nature Structural Biology 1998, 5, 289-293
DOI: 10.1038/nsb0498-289
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68. The role of surface perfection in chemical force microscopy
R McKendry, M-E Theoclitou, C Abell and T Rayment
Langmuir 1988, 14, 2846-2849
DOI: 10.1021/la970374e
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67. Solid phase aldol and conjugate addition reactions using the Evans' oxazolidinone chiral auxiliary
CW Phoon and C Abell
Tetrahedron Lett. 1998, 2655-2658
DOI: 10.1016/S0040-4039(98)00230-5
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66. Synthesis of 2-bromo- and 2-fluoro-3-dehydroshikimic acids and 2-bromo- and 2-fluoroshikimic acids using synthetic and enzymatic approaches
C González-Bello, MK Manthey, JH Harris, AR Hawkins, JR Coggins and C Abell
J. Org. Chem. 1998, 63, 1591-1597
DOI: 10.1021/jo971858i
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65. Chiral discrimination by chemical force microscopy
R McKendry, M-E Theoclitou, T Rayment and C Abell
Nature 1998, 361, 566-568
DOI: 10.1038/35339
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64. Solution phase synthesis of 2,6,9-trisubstituted purines
MT Fiorini and C Abell
Tetrahedron Lett. 1998, 1827-1830
DOI: 10.1016/S0040-4039(98)00098-7
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63. Derailing dehydroquinate synthase by introducing a stabilising stereoelectronic effect in a reaction intermediate
EJ Parker, JR Coggins and C Abell
J. Org. Chem. 1997, 62, 8582-8585
DOI: 10.1021/jo9713060
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62. Studies on the synthesis, characterisation and reactivity of aromatic diboronic acids
MH Todd, S Balasubramanian and C Abell
Tetrahedron Lett. 1997, 6781-6784
DOI: 10.1016/S0040-4039(97)01552-9
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61. A combinatorial approach to identifying protein tyrosine phosphatase substrates from a phosphotyrosine peptide library
YW Cheung, C Abell and S Balasubramanian
J. Am. Chem. Soc. 1997, 119, 9568-9569
DOI: 10.1021/ja971825k
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60. Synthesis of 2-oxindole derivatives via the intramolecular Heck reaction on solid support
V Arumugam, A Routledge, C Abell and S Balasubramanian
Tetrahedron Lett. 1997, 6437-6476
DOI: 10.1016/S0040-4039(97)01481-0
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59. Synthesis of tetrahydroquinolines, hexahydrobenzoindolizines and an aryl phosphonate linker for the generation of catalytic antibodies
C González-Bello, C Abell and FJ Leeper
J. Chem. Soc., Perkin Trans. 1 1997, 1017-1024
DOI: 10.1039/A606968A
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58. Escherichia coli L-aspartate-alpha-decarboxylase: preprotein processing and observation of reaction intermediates by mass spectrometry
MK Ramjee, U Genschel, C Abell and AG Smith
Biochem. J. 1997, 323, 661-669
DOI: 10.1042/bj3230661
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57. Synthesis of (2R)-2-bromodehydroquinic acid and (2R)-2-fluorodehydroquinic acid
MK Manthey, C González-Bello and C Abell
J. Chem. Soc. Perkin Trans. 1 1997, 625-628
DOI: 10.1039/A606104D
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56. The use of a dithiane protected benzoin photolabile safety catch linker for solid phase synthesis
A Routledge, C Abell and S Balasubramanian
Tetrahedron Lett. 1997, 1227-1230
DOI: 10.1016/S0040-4039(96)02478-1
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55. Lipophilic modification of oligonucleotides
JM Tomkins, KJ Barnes, AJ Blacker, WJ Watkins and C Abell
Tetrahedron Lett. 1997, 38, 691-694
DOI: 10.1016/S0040-4039(96)02394-5
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54. An investigation into solid-phase radical chemistry - synthesis of furan rings
A Routledge, C Abell and S Balasubramanian
Synlett. 1997, 61-62
DOI: 10.1055/s-1997-704
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53. Approaches to antibody-catalysed cationic cyclisations: chemical studies of leaving groups and cyclisation modes
C Lawrence, IM Bell, C Abell and FJ Leeper
Israeli J. Chem. 1996, 36, 161-169
DOI: 10.1002/ijch.199600022
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52. Evidence from kinetic isotope studies for an enolate intermediate in the mechanism of type II dehydroquinases
JM Harris, C González-Bello, C Kleanthous, AR Hawkins, JR Coggins and C Abell
Biochem. J. 1996, 319, 333-336
DOI: 10.1042/bj3190333
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51. Comparison of the substrate specificity of type I and type II dehydroquinases with 5-deoxy- and 4,5-dideoxydehydroquinic acid
JM Harris, WJ Watkins, AR Hawkins, JR Coggins and C Abell
J. Chem. Soc., Perkin Trans. I 1996, 2371-2377
DOI: 10.1039/p19960002371
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50. An electrochemical study to model the chorismate synthase reaction
M-E Theoclitou, PJ Duggan and C Abell
Bioorg. and Med. Chem. Lett. 1996, 6, 1285-1288
DOI: 10.1016/0960-894X(96)00217-X
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49. Enzymatic synthesis of (6R)- and (6S)-fluoroshikimic acids
PJ Duggan, E Parker, JR Coggins and C Abell
Bioorg. and Med. Chem. Lett. 1995, 5, 2347-2352
DOI: 10.1016/0960-894X(95)00405-I
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48. Escherichia coli chorismate synthase catalyses the conversion of (6S)-6-fluoro-5-enolpyruvylshikimate-3-phosphate to 6-fluorochorismate
S Bornemann, MK Ramjee, S Balasubramanian, C Abell, JR Coggins, DJ Lowe and RNF Thorneley
J. Biol. Chem. 1995, 270, 22811-22815
DOI: 10.1074/jbc.270.39.22811
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47. Escherichia coli chorismate synthase: a deuterium kinetic isotope effect under single turnover and steady state conditions shows that a flavin intermediate forms before the C-(6proR)-H bond is cleaved
S Bornemann, S Balasubramanian, JR Coggins, C Abell, DJ Lowe and RNF Thorneley
Biochem. J. 1995, 305, 707-710
DOI: 10.1042/bj3050707
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46. Escherichia coli dihydrodipicolinate synthase: characterisation of the imine intermediate and the product of bromopyruvate treatment by electrospray mass spectrometry
EB Borthwick, SJ Connell, DW Tudor, DJ Robins, A Shneier, C Abell and JR Coggins
Biochem. J. 1995, 305, 521-524
DOI: 10.1042/bj3050521
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45. Observation of a secondary tritium isotope effect in the chorismate synthase reaction
S Balasubramanian, JR Coggins and C Abell
Biochemistry 1995, 34, 341-348
DOI: 10.1021/bi00001a042
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44. The resolution of diterpene cyclase activities from Ricinus Communis
CM Spickett , K Ponnamperuma and C Abell
Phytochemistry 1994, 37, 971-973
DOI: 10.1016/S0031-9422(00)89511-4
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43. Design and synthesis of transition state analogues for a cationic cyclisation
IM Bell, C Abell and FJ Leeper
J. Chem. Soc., Perkin Trans. 1 1994, 1997-2006 DOI: 10.1039/P19940001997
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42. Tandem overproduction and characterisation of the nuclease domain of colicin E9 and its cognate inhibitor protein Im9
R Wallis, A Reilly, K Barnes, C Abell, DG Campbell, GR Moore, R James and C Kleanthous
Eur. J. Biochem. 1994, 220, 447-454
DOI: 10.1111/j.1432-1033.1994.tb18642.x
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41. Evidence for the pathway to pantothenate in plants
CE Jones, JE Dancer, AG Smith and C Abell
Can. J. Chem. 1994, 72, 261-263
DOI: 10.1139/v94-039
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40. Studies on Escherichia coli chorismate synthase
S Bornemann, M N Manjee, DJ Lowe, RNF Thorneley, JR Coggins, C Abell, S Balasubramanian, TR Hawkes, WW Nichols and GM Davies
Proceedings of the Eleventh International Symposium on Flavins and Flavoproteins, Walter de Gruyter & Co., Berlin 1994
ISBN 978-3110141658
pp843-846
39. Different mechanistic and stereochemical courses for the reactions catalysed by type I and type II dehydroquinases
J Harris, C Kleanthous, JR Coggins, AR Hawkins and C Abell
J. Chem. Soc., Chem. Commun. 1993, 1080-1081
DOI: 10.1039/C39930001080
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38. Evidence for opposite stereochemical courses for the reactions catalysed by type I and type II dehydroquinases
A Shneier, J Harris, C Kleanthous, JR Coggins, AR Hawkins and C Abell
BioMed. Chem. Lett. 1993, 3, 1399-1402
DOI: 10.1016/S0960-894X(01)80419-4
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37. Cloning and sequencing of the E. coli panB gene, encoding ketopantoate hydroxymethyltransferase, and overexpression of the enzyme
CE Jones, JM Brook, D Buck, C Abell and AG Smith
J. Bacteriol. 1993, 175, 2125-2130
DOI: 10.1128/jb.175.7.2125-2130.1993
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36. Purification, characterisation, crystallisation and x-ray analysis of selenomethionine-labelled hydroxymethylbilane synthase from Escherichia coli
A Hädener, PK Matzinger, VN Malashkevich, GV Louie, SP Wood, P Oliver, PR Alefounder, AR Pitt, C Abell and AR Battersby
Eur. J. Biochem. 1993, 211, 615-624
DOI: 10.1111/j.1432-1033.1993.tb17589.x
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35. Enzymatic formation of lactams on organic solvents
AL Gutman, E Meyer, X Yue and C Abell
Tetrahedron Lett. 1992, 33, 3943-3946
DOI: 10.1016/S0040-4039(00)74825-8
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34. Reaction of (6R)-6-F-EPSP with recombinant Escherichia coli chorismate synthase generates a stable flavin mononucleotide semiquinone radical
MN Ramjee, S Balasubramanian, C Abell, JR Coggins, GM Davies, TR Hawkes, DJ Lowe, and RNF Thorneley
J. Am. Chem. Soc. 1992, 114, 3151-3153
DOI: 10.1021/ja00034a079
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33. Post-translational modification of Klebsiella pneumoniae flavodoxin by covalent attachment of coenzyme A shown by 31P NMR and electrospray mass spectrometry, prevents electron transfer from the nifJ protein to nitrogenase. A possible new regulatory mechanism for biological nitrogen fixation
RNF Thorneley, C Abell, GA Ashby, MH Drummond, RR Eady, S Huff, CJ Macdonald and A Shneier
Biochemistry 1992, 31, 1216-1244
DOI: 10.1021/bi00119a035
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32. Observation of an imine intermediate in the dehydroquinase reaction by electrospray mass spectrometry
A Shneier, C Kleanthous, R Deka, JR Coggins and C Abell
J. Am. Chem. Soc. 1991, 113, 9416-9418
DOI: 10.1021/ja00024a085
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31. Inhibition of chorismate synthase by (6R)- and (6S)-6-fluoro-5-enolpyruvylshimate 3-phosphate
S Balsubramanian, GM Davies, JR Coggins and C Abell
J. Am. Chem. Soc. 1991, 113, 8945-8946
DOI: 10.1021/ja00023a051
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30. Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition-elimination reactions
DE Cane, C Abell, PHM Harrison, BR Hubbard, CT Kane, R Lattman, JS Oliver and SW Weiner
Phil. Trans. Roy. Soc., London Series B Biol. Sci. 1991, 332, 123-129
DOI: 10.1098/rstb.1991.0040
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29. Uroporphyrinogen III synthase: studies on its mechanism of action, molecular biology, and biochemistry
N Crockett, PR Alefounder, AR Battersby and C Abell
Tetrahedron 1991, 47, 6003-6014
DOI: 10.1016/S0040-4020(01)86492-9
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28. An amino acid sequence motif observed amongst enzymes of the shikimate pathway
TDH Bugg, PR Alefounder and C Abell
Biochem. J. 1991, 276, 841-843
DOI: 10.1042/bj2760841
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27. Studies on the mechanism of hydroxymethylbilane synthase concerning the role of arginines in substrate binding
M Lander, A R Pitt, PR Alefounder, C Abell and AR Battersby
Biochem. J. 1991, 275, 447-452
DOI: 10.1042/bj2750447
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26. The synthesis of [6-2H]enolpyruvylshikimate-3-phosphate
S Balasubramanian and C Abell
Tetrahedron Lett. 1991, 963-966
DOI: 10.1016/S0040-4039(00)92131-2
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25. Observation of an isotope effect in the chorismate synthase reaction
S Balasubramanian, C Abell and JR Coggins
J. Am. Chem. Soc. 1990, 112, 8581-8583
DOI: 10.1021/ja00179a052
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24. Biosynthesis of pentalenene and pentalenolactone
DE Cane, JS Oliver, PHM Harrison, C Abell, BR Hubbard, CT Kane and R Lattman
J. Am. Chem. Soc. 1990, 112, 4513-4524
DOI: 10.1021/ja00167a059
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23. Investigation of putative active site lysine residues in hydroxymethylbilane synthase: preparation and characterisation of mutants in which (a) Lys-55, (b) Lys-59 and (c) both Lys-55 and 59 have been replaced by glutamine
A Hädener, PR Alefounder, GJ Hart, C Abell and AR Battersby
Biochem. J. 1990, 271, 487-491
DOI: 10.1042/bj2710487
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22. Isolation and characterisation of a cDNA clone for a chlorophyll synthesis enzyme from Euglena gracilis
AL Sharif, AG Smith and C Abell
Eur. J. Biochem 1989, 184, 353-359
DOI: 10.1111/j.1432-1033.1989.tb15026.x
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21. Evidence that the pyridoxal phosphate modification of lysine residues (Lys-55 and Lys-59) causes inactivation of hydroxymethylbilane synthase (porphobilinogen deaminase)
AD Miller, LC Packman, GJ Hart, PR Alefounder, C Abell and AR Battersby
Biochem. J. 1989, 262, 119-124
DOI: 10.1042/bj2620119
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20. Biosynthesis of the pigments of life: structure and mode of action of a novel enzymatic cofactor
PR Alefounder, GJ Hart, AD Miller, U Beifuss, C Abell, FJ Leeper and AR Battersby
Bioorg. Chem. 1989, 17, 121-129
DOI: 10.1016/0045-2068(89)90013-8
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19. Affinity labelling of E. coli dehydroquinase
TDH Bugg, C Abell and JR Coggins
Tetrahedron Lett. 1988, 6783-6786
DOI: 10.1016/S0040-4039(00)82454-5
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18. Specificity of E. coli shikimate dehydrogenase towards analogues of 3-dehydroshikimic acid
TDH Bugg, C Abell and JR Coggins
Tetrahedron Lett. 1988, 6779-6782
DOI: 10.1016/S0040-4039(00)82453-3
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17. The absolute stereochemistry of the enzymic cyclisation to form the sterpurene sesquiterpenes
C Abell and AP Leech
Tetrahedron Lett. 1988, 4337-4340
DOI: 10.1016/S0040-4039(00)80491-8
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16. The sequence of hemC, hemD and two additional E. coli genes
PR Alefounder, C Abell and AR Battersby
Nucl. Acids Res. 1988, 16, 9871
DOI: 10.1093/nar/16.20.9871
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15. Pentalenene biosynthesis and the enzymatic cyclisation of farnesyl pyrophosphate. Anti stereochemistry in a biological SE' reaction.
DE Cane, C Abell, R Lattman, C T Kane, BR Hubbard and PR Harrison
J. Am. Chem. Soc. 1988, 110, 4081-4082
DOI: 10.1021/ja00220a081
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14. The absolute configuration of the sterpurene sesquiterpenes
C Abell and AP Leech
Tetrahedron Lett. 1988, 1985-1986
DOI: 10.1016/S0040-4039(00)82096-1
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13. Structure of (-)-3-dehydroshikimic acid monohydrate
C Abell, FH Allen, TDH Bugg, MJ Doyle and PR Raithby
Acta Cryst. 1988, C44, 1290-1292
DOI: 10.1107/S0108270188002896
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12. Structure of (-)-quinic acid
C Abell, FH Allen, TDH Bugg, MJ Doyle and PR Raithby
Acta Cryst. 1988, C44, 1287-1290
DOI: 10.1107/S0108270188002884
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11. Structure of sodium (-)-shikimate dihydrate
C Abell, FH Allen, TDH Bugg, MJ Doyle and PR Raithby
Acta Cryst. 1988, C44, 1204-1207
DOI: 10.1107/S0108270188002872
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10. Evidence for consecutive 1,2-alkyl shifts in sterpurene biosynthesis: isolation and characterisation of 7,12-dihydroxysterpurene
C Abell and AP Leech
Tetrahedron Lett. 1987, 4887-4890
DOI: 10.1016/S0040-4039(00)96652-8
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9. Studies on the biosynthesis of hydroxymellein using 17O NMR and 2H NMR spectroscopy to determine the origin of the C-4 hydroxyl group
C Abell, AC Sutkowski and J Staunton
J. Chem. Soc., Chem. Commun. 1987, 586-587
DOI: 10.1039/C39870000586
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8. Purification, N-terminal amino acid sequence and properties of hydroxymethylbilane synthase (porphobilinogen deaminase) from Escherichia coli
GJ Hart, C Abell and AR Battersby
Biochem. J. 1986, 240, 273-276
DOI: 10.1042/bj2400273
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7. The use of NMR spectroscopy to follow deuterium in studies of fungal metabolism
C Abell (1986)
In "Modern Methods of Plant Analysis" Vol. 2, ed. H F Linskens & J F Jackson, Springer-Verlag, Berlin, 1986
ISBN: 354015910x
pp60-89
6. Biomimetic syntheses of the heptaketide fungal metabolites alternariol and rubrofusarin: models for cyclisation reactions catalysed by polyketide synthase enzymes
C Abell, BD Bush and J Staunton
J. Chem. Soc., Chem. Commun. 1986, 15-17
DOI: 10.1039/C39860000015
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5. Pentalenene biosynthesis and the enzymatic cyclisation of farnesyl pyrophosphate: proof that the cyclisation is catalysed by a single enzyme
DE Cane, C Abell and AM Tillman
Bioorganic Chemistry 1984, 12, 312-328
DOI: 10.1016/0045-2068(84)90013-0
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4. Biosynthesis of 6-methylsalicylic acid: the combined use of mono- and trideuteriated acetate precursors to investigate the degree of stereocontrol in the aromatisation sequence
C Abell and J Staunton
J. Chem. Soc., Chem. Commun. 1984, 1005-1007
DOI: 10.1039/C39840001005
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3. Biosynthesis of the polyketide mellein from CD3CO2H and 13CD3CO2H in Aspergillus melleus: detection of deuterium by 2H NMR and edited 13C NMR spectra
C Abell, DM Doddrell, MJ Garson, ED Laue and J Staunton
J. Chem. Soc., Chem. Commun. 1983, 694-696
DOI: 10.1039/C39830000694
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2. Biosynthesis of the fungal metabolites alternariol, mellein, rubrofusarin, and 6-methylsalicylic acid from CD3CO2H.
C Abell, MJ Garson, FJ Leeper and J Staunton
J. Chem. Soc., Chem. Commun. 1982, 1011-1013
DOI: 10.1039/C39820001011
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1. The use of 2H NMR spectroscopy and β-isotopic shifts in the 13C NMR spectrum to measure deuterium retention in the biosynthesis of the polyketide 6-methylsalicylic acid
C Abell and J Staunton
J. Chem. Soc., Chem. Commun. 1981, 856-858
DOI: 10.1039/C39810000856
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